化学合成
候補化合物が選択されると、化学合成が行われ、設計されたハイブリッド化合物が生成される。これは，エトポシド類似体とシロイヌナズナ成分との結合に関与する可能性があり，得られた分子が必要な結合性質を保つことを確保している。
化学原料を購入する必要がある場合は、 要求情報を送信してください最新の見積りを入手してください。
化学合成の学術論文
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Structure-based design, synthesis and biological testing of etoposide analog epipodophyllotoxin-N-mustard hybrid compounds designed to covalently bind to topoisomerase II and DNA
関連化学物質
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4β-chloroacetamido-4-deoxy-4′-desmethylepipdophyllotoxin
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Synthesis and pharmacological testing of polyaminoquinolines as blockers of the apamin-sensitive Ca2+-activated K+ channel (SKCa)
関連化学物質
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4-(3-AMINOPROP-1-YL)AMINOQUINOLINE
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Synthesis and characterization of a fluorescent analogue of methotrexate
関連化学物質
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N~2~-(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)amino}benzoyl)-D-lysine
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Synthesis, evaluation and docking studies on 3-alkoxy-4-methanesulfonamido acetophenone derivatives as non ulcerogenic anti-inflammatory agents
関連化学物質
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1-(4-amino-3-n-butoxyphenyl)ethanone
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Design, Synthesis, and Biological Evaluation of Tetrahydro-β-carboline Derivatives as Selective Sub-Nanomolar Gelatinase Inhibitors
関連化学物質
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(1RS)-2-(4''-methoxy-4'-phenoxybenzenesulfonyl)-1,2,3,4-tetrahydro-norarmano-1-carboxylic acid
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Discovery of biphenylacetamide-derived inhibitors of BACE1 using de novo structure-based molecular design
関連化学物質
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2-([1,1'-biphenyl]-4-yl)-N-(4-methoxybenzyl)acetamide
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Design, synthesis, and biological evaluation of N-acetyl-2-(or 3-)carboxymethylbenzenesulfonamides as cyclooxygenase isozyme inhibitors
関連化学物質
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4-fluoro-2-(methoxycarbonylmethyl)benzenesulfonamide
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Pyridine analogues of nimesulide: Design, synthesis, and in vitro and in vivo pharmacological evaluation as promising cyclooxygenase 1 and 2 inhibitors
関連化学物質
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4-nitro-3-(3-bromophenylamino)pyridine N-oxide
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Design and synthesis of new transition-state analogue inhibitors of aspartate transcarbamylase
関連化学物質
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dibenzyl N-(phosphonoacetyl)aspartate
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Design, synthesis, antimycobacterial evaluation, and in silico studies of 3-(phenylcarbamoyl)-pyrazine-2-carboxylic acids
関連化学物質
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3-(anilinocarbonyl)-2-pyrazinecarboxylic acid
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Synthesis and phosphodiesterase 5 inhibitory activity of new 5-phenyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one derivatives containing an N-acylamido group on a phenyl ring
関連化学物質
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1-Methyl-5-(5-nitro-2-propoxyphenyl)-3-propyl-1,4-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one
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Synthesis, characterization and biological activity of ring-substituted 6-benzylamino-9-tetrahydropyran-2-yl and 9-tetrahydrofuran-2-ylpurine derivatives
関連化学物質
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6-(4-methoxybenzylamino)-9-(tetrahydropyran-2-yl)-9H-purine
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Synthesis of new substance P analogues releasing histamine from rat peritoneal mast cells
関連化学物質
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Boc-Pro-Lys(Z)-Pro-OCH3
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Synthesis and Evaluation of 1- and 2-Substituted Fentanyl Analogues for Opioid Activity
関連化学物質
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Carbamic acid, [2-oxo-2-[(2-phenylethyl)amino]ethyl]-, phenylmethyl ester
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Structure-based design of 5-Methylpyrimidopyridone derivatives as new wild-type sparing inhibitors of the epidermal growth factor receptor triple mutant (EGFRL858R/T790M/C797S)
関連化学物質
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bis(benzonitrile)palladium(II) dichloride
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tert-butyl (S)-3-((5-bromo-2-chloropyrimidin-4-yl)amino)piperidine-1-carboxylate
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Synthesis and Biological Activity of the Four Stereoisomers of 6-<4-<3-<<2-Hydroxy-3-<4-<2-(cyclopropylmethoxy)ethyl>phenoxy>propyl>amino>propionamido>phenyl>-5-methyl-4,5-dihydro-3(2H)-pyridazinone, a Combined Vasodilator and β-Adrenoceptor Antagonist
関連化学物質
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シリカゲル
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2-Propanol, 1-amino-3-[4-[2-(cyclopropylmethoxy)ethyl]phenoxy]-, (S)-
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Preparation of phosphonooxymethyl prodrugs of HIV-1 attachment inhibitors
関連化学物質
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{3-[(4-benzoylpiperazin-1-yl)(oxo)acetyl]-4,7-dimethoxy-1H-pyrrolo[2,3-c]pyridin-1-yl}methyl dihydrogen phosphate
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Synthesis and study of 2-amino-7-bromofluorenes modified with nitroxides and their precursors as dual anti-amyloid and antioxidant active compounds
関連化学物質
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7-bromo-N-[(1-oxyl-4-bromo-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-yl)methyl]-9H-fluoren-2-amine radical
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Synthesis of arylidene-substituted gelastatin analogues and their screening for MMP-2 inhibitory activity
関連化学物質
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トリエチルアミン
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9-BBN
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anisaldehyde
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Structure-based de novo design of ligands using a three-dimensional model of the insulin receptor
関連化学物質
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Hexanoic acid, 4-oxo-6-[[(phenylmethoxy)carbonyl]amino]-
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Design, synthesis, and biological evaluation of a potent, PKC selective, B-ring analog of bryostatin
関連化学物質
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{(S)-3-Benzyloxy-1-[(2S,6R)-6-((R)-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl)-tetrahydro-pyran-2-ylmethyl]-propoxy}-tert-butyl-diphenyl-silane
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Design, synthesis and characterization of N9/N7-substituted 6-aminopurines as VEGF-R and EGF-R inhibitors
関連化学物質
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Ethanone, 2-(6-amino-9H-purin-9-yl)-1-phenyl-
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Design, synthesis, and evaluation of water-soluble morpholino-decorated paclitaxel prodrugs with remarkably decreased toxicity
関連化学物質
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2’-(4-nitrophenoxycarbonyl)paclitaxel
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Synthesis and biological evaluation of orally active matrix metaloproteinase inhibitors
関連化学物質
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(2R)-2-bromo-4-methylpentanoic acid t-butyl ester
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Design, synthesis, and activity evaluation of novel N-benzyl deoxynojirimycin derivatives for use as α-glucosidase inhibitors
関連化学物質
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2,3-dibromo-1-(bromomethyl)-4,5-dimethoxybenzene
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Studies on the synthesis of nicotinamide nucleoside and nucleotide analogues and their inhibitions towards CD38 nadase
関連化学物質
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((3aR,5R,6S,6aS)-6-fluoro-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)methyl benzoate
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Synthesis and Evaluation of Dolastatin 10 Analogues Containing Heteroatoms on the Amino Acid Side Chains
関連化学物質
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1-Pyrrolidinecarboxylic acid, 2-[(1R,2R)-1-methoxy-2-methyl-3-oxo-3-[(2-phenylethyl)amino]propyl]-, 1,1-dimethylethyl ester, (2S)-
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Design, synthesis, and biological evaluation of novel piperidine-4- carboxamide derivatives as potent CCR5 inhibitors
関連化学物質
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tert-butyl 4-(4-cyanobenzylcarbamoyl)piperidine-1-carboxylate
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Synthesis and evaluation of 2′,4′,6′-trihydroxychalcones as a new class of tyrosinase inhibitors
関連化学物質
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4H-1-Benzopyran-4-one, 2-(2,4-dihydroxyphenyl)-2,3-dihydro-5,7-dihydroxy-
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Preparation and biological evaluation of conformationally constrained BACE1 inhibitors
関連化学物質
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ethyl (8R,9S)-8-[[(1R)-1-phenylethyl]amino]-1,4-dioxaspiro[4.5]decane-9-carboxylate
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Systematic synthesis of novel phosphoglycolipid analogues as potential agonists of GPR55
関連化学物質
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(((15-bromopentadecyl)oxy)methyl)benzene
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Design, synthesis and biological evaluation of novel thieno[3,2-d] pyrimidine derivatives containing diaryl urea moiety as potent antitumor agents
関連化学物質
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2-(4-nitrophenyl)-4-hydroxythieno[3,2-d]pyrimidine
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Synthesis and structure-activity relationships of di- and trisaccharide inhibitors for Shiga-like toxin Type 1
関連化学物質
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methyl 2,3,6-tri-O-benzoyl-4-O-(2,3,4,6-tetra-O-benzyl-α-D-galactopyranosyl)-β-D-galactopyranoside
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Scaffold hopping strategy toward original pyrazolines as selective CB 2 receptor ligands
関連化学物質
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1-(4-chloro-3-methylphenyl)heptan-1-one
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Design and synthesis of triarylacrylonitrile analogues of tamoxifen with improved binding selectivity to protein kinase C
関連化学物質
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Benzeneacetonitrile, a-[bis[4-[2-(diethylamino)ethoxy]phenyl]methylene]-
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Synthesis, pharmacological evaluation and docking studies of coumarin derivatives
関連化学物質
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4-methyl-2-oxo-2H-chromen-7-yl N-phenylglycinate
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Design and synthesis of resveratrol-based nitrovinylstilbenes as antimitotic agents
関連化学物質
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(E)-2-(4-fluorostyryl)-3,4,5-trimethoxybenzaldehyde
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Synthesis of novel indole hydrazone derivatives and evaluation of their antiplatelet aggregation activity
関連化学物質
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(2E)-2-(2,2-diphenylethylidene)hydrazinecarboxamide
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Design, synthesis and anticancer activities of hybrids of indole and barbituric acids-Identification of highly promising leads
関連化学物質
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INDOLE-3-CARBOXALDEHYDE
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バルビツール酸
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C22H19N3O5S
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Synthesis and characterization of novel azo-morphine derivatives for possible use in abused drugs analysis
関連化学物質
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塩酸アニリン
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コデイン
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sodium hydroxide
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Synthesis and calcium mobilization activity of cADPR analogues which integrate nucleobase, northern and southern ribose modifications
関連化学物質
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(2R,3S,4R,5R)-5-((benzoyloxy)methyl)-3-chlorotetrahydrofuran-2,4-diyl dibenzoate
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Synthesis of novel N-branched acyclic nucleoside phosphonates as potent and selective inhibitors of human, plasmodium falciparum and plasmodium vivax 6-oxopurine phosphoribosyltransferases
関連化学物質
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diethyl 2-((2-hydroxyethyl)(2-(trityloxy)ethyl)amino)ethylphosphonate
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シリカゲル
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Structure-affinity relationships of the affinity of 2-pyrazolyl adenosine analogues for the adenosine A2A receptor
関連化学物質
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1-(cyclohexylmethyl)-4-iodo-1H-pyrazole
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Synthesis and Biological Evaluation of New Combined α/β-Adrenergic Blockers
関連化学物質
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フマル酸
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1-(3-Methoxymethyl-4-oxiranylmethoxy-phenyl)-ethanone
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