ハイスループットスクリーニング(HTS)
HTSは、比較的短い時間で大量の化合物がカリウムチャネルを遮断する能力を試験することに関する。自動化とロボット技術はこの過程を加速させるためによく使われる。
化学原料を購入する必要がある場合は、 要求情報を送信してください最新の見積りを入手してください。
ハイスループットスクリーニング(HTS)の学術論文
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Identification of a novel fluoropyrrole derivative as a potassium-competitive acid blocker with long duration of action
関連化学物質
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1-[5-(2-Fluoropyridin-3-yl)-1-(phenylsulfonyl)-1H-pyrrol-3-yl]-N-methylmethanamine fumarate
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Discovery of a novel small molecule agonist scaffold for the APJ receptor
関連化学物質
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(2S)-cyclohexyl({[5-(2,6-dimethoxyphenyl)-1-(4-fluorophenyl)-1H-pyrazol-3-yl]carbonyl}amino)ethanoic acid
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Identification of a potent and selective free fatty acid receptor 1 (FFA1/GPR40) agonist with favorable physicochemical and in vitro ADME properties
関連化学物質
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methyl 3-(4-((2-chloropyridin-4-yl)ethynyl)phenyl)propanoate
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Development of new LXR modulators that regulate LXR target genes and reduce lipogenesis in human cell models
関連化学物質
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4-(bromomethyl)-N-cyclohexyl-N-methylbenzenesulfonamide
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Identification of arginine analogues as antagonists and agonists for the melanocortin-4 receptor
関連化学物質
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(S)-2-TERT-BUTOXYCARBONYLAMINO-3-NAPHTHALEN-2-YL-PROPIONIC ACID METHYL ESTER
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Discovery and structural development of small molecules that enhance transport activity of bile salt export pump mutant associated with progressive familial intrahepatic cholestasis type 2
関連化学物質
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methyl 3-{N-(1-butyl)-2-chloro-4-{[3-(2,6-dichlorophenyl)-5-isopropylisoxazol-4-yl]methoxy}benzamido}benzoate
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Identification of a potent small-molecule inhibitor of bacterial DNA repair that potentiates quinolone antibiotic activity in methicillin-resistant Staphylococcus aureus
関連化学物質
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2-(4-{[(3-fluorophenyl)amino]carbonothioyl}-1-piperazinyl)-8-ethyl-5-oxo-5,8-dihydropyrido[2,3-d]pyrimidine-6-carboxylic acid
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Identification of potent non-peptide somatostatin antagonists with sst3 selectivity
関連化学物質
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2-tert-butoxycarbonylamino-3-(1H-indol-3-yl)-propionic acid 2-oxo-1,2-diphenyl-ethyl ester
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Synthesis of selective inhibitors against V. cholerae sialidase and human cytosolic sialidase NEU2
関連化学物質
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methyl acetamido-2,6-anhydro-3,5-dideoxy-9-p-toluenesulfonyl-D-glycero-D-galactonon-2-enonate
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Rational discovery of a highly novel and selective mTOR inhibitor
関連化学物質
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1-cyclopropyl-3-(4-(5-(2,2-difluoropropyl)-6a-methyl-6-oxo-5,6,6a,7,9,10-hexahydro[1,4]oxazino[3,4-h]pteridin-2-yl)phenyl)urea
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Discovery of imidazopyridazines as potent Pim-1/2 kinase inhibitors
関連化学物質
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(S)-tert-butyl 1-(3-aminopyridin-4-yl)piperidin-3-ylcarbamate
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2,6-Disubstituted imidazo[2,1-b][1,3,4]thiadiazoles: Search for anticancer agents
関連化学物質
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2-(2-fluorobiphenyl-4-yl)-6-phenylimidazo[2,1-b][1,3,4]thiadiazole
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Discovery of selective LRRK2 inhibitors guided by computational analysis and molecular modeling
関連化学物質
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5-chloro-N4-methyl-N2-phenylpyrimidine-2,4-diamine
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Integration of optimized substituent patterns to produce highly potent 4-aryl-pyridine glucagon receptor antagonists
関連化学物質
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[4-(2-benzyloxy-4-fluoro-phenyl)-2,6-diisopropyl-5-vinyl-pyridin-3-yl]-methanol
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Identification of 4-amino-2-cyclohexylaminoquinazolines as metabolically stable melanin-concentrating hormone receptor 1 antagonists
関連化学物質
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[4-(1,3-dioxo-1,3-dihydro-isoindol-2-ylmethyl)-cyclohexyl]-carbamic acid tert-butyl ester
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Accelerating lead optimization of chromone carboxamide scaffold throughout microwave-assisted organic synthesis
関連化学物質
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N-(3-chlorophenyl)-4-oxo-4H-chromene-2-carboxamide
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Synthesis and estrogen receptor affinity of 2,3-diarylindoles
関連化学物質
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1H-Indol-5-ol, 2,3-diphenyl-
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Structure-activity relationships of arylbenzofuran H3 receptor antagonists
関連化学物質
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4-(3-bromo-2-{2-[(2R)-2-methylpyrrolidin-1-yl]ethyl}-1-benzofuran-5-yl)benzonitrile
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Phenoxypropanolamine derivatives as selective inhibitors of the 20S proteasome β1 and β5 subunits
関連化学物質
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(4-thien-2-yltetrahydropyran-4-yl)methylamine
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Trypanosoma cruzi Malic Enzyme Is the Target for Sulfonamide Hits from the GSK Chagas Box
関連化学物質
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3-AMINO-N-(4-METHOXY-PHENYL)-BENZENESULFONAMIDE
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Structure-based discovery of pyrazolobenzothiazine derivatives as inhibitors of hepatitis C virus replication
関連化学物質
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methyl 1-(4-fluorophenyl)-4-methyl-1,4-dihydropyrazolo[4,3-c][1,2]benzothiazine-3-carboxylate 5,5-dioxide
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4-Alkoxybenzamidines as new potent phospholipase A2 inhibitors
関連化学物質
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Benzenecarboximidamide, 4-(octyloxy)-
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Novel cAMP PDE III Inhibitors: 1,6-Naphthyridin-2(1H)-ones
関連化学物質
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5-(4-aminophenyl)-1,6-naphthyridin-2(1H)-one
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Promiscuity and selectivity in covalent enzyme inhibition: A systematic study of electrophilic fragments
関連化学物質
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2-Propenamide, N-(4-fluorophenyl)-
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PPARγ-sparing thiazolidinediones as insulin sensitizers. Design, synthesis and selection of compounds for clinical development
関連化学物質
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5-[[4-(2-oxo-2-phenylethoxy)phenyl]methyl]-2,4-thiazolidinedione
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Double asymmetric iodoamination; synthesis of C2 symmetric and meso-amino alcohols
関連化学物質
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((1S,2R,3S,4R)-1-Benzyl-4-tert-butoxycarbonylamino-2,3-dihydroxy-5-phenyl-pentyl)-carbamic acid tert-butyl ester
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Discovery of novel quinolinone adenosine A2B antagonists
関連化学物質
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2-(1,3-thiazol-2-yl)acetonitrile
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Arylamidrazones as novel corticotropin releasing factor receptor antagonists
関連化学物質
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C10H8BrF3N2O
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Identification of a new biaryl scaffold generating potent renin inhibitors
関連化学物質
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1,3-dichloro-2-{2-[4-(iodomethyl)phenoxy]ethoxy}-5-methylbenzene
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New antiprotozoal agents: Their synthesis and biological evaluations
関連化学物質
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N-{3-benzyl-2-[4-fluoro-2-(1-hydroxyethyl)phenoxy]quinolin-6-yl}-(3-trifluoromethylphenyl)sulfonamide
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Synthesis and evaluation of acyl protein thioesterase 1 (APT1) inhibitors
関連化学物質
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Butanoic acid, 2-[bis[(1,1-dimethylethoxy)carbonyl]amino]-4-oxo-, methyl ester, (2S)-
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Chemoproteomics-Enabled Discovery of a Potent and Selective Inhibitor of the DNA Repair Protein MGMT
関連化学物質
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4-(2-(5-(chloromethyl)-4-(4-(trifluoromethoxy)phenyl)-1H-1,2,3-triazol-1-yl)ethyl)-3,5-dimethylisoxazole
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Identification of agonists and antagonists of the human melanocortin-4 receptor from piperazinebenzylamines
関連化学物質
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[2-[4-(2-acetyl-phenyl)-piperazin-1-yl]-1-(4-chloro-benzyl)-2-oxo-ethyl]-carbamic acid tert-butyl ester
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Design and modular parallel synthesis of a MCR derived α-helix mimetic protein-protein interaction inhibitor scaffold
関連化学物質
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5-[ISOCYANO-(TOLUENE-4-SULFONYL)-METHYL]-BENZO[1,3]DIOXOLE
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Design, synthesis, and structure-activity relationships of novel bicyclic azole-amines as negative allosteric modulators of metabotropic glutamate receptor 5
関連化学物質
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2-(2-phenyl-6,7-dihydrooxazolo[4,5-c]pyridin-5(4H)-yl)nicotinonitrile
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Identification of novel mammalian squalene synthase inhibitors using a three-dimensional pharmacophore
関連化学物質
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Acetic acid (3aS,4R,5S,6aR)-4-acetoxymethyl-2-oxo-hexahydro-cyclopenta[b]furan-5-yl ester
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