体外試験
次に，合成した化合物を癌細胞株を用いて体外試験した。細胞毒性、DNA損傷を誘導する能力、およびトポイソメラーゼIIとの相互作用を評価した。細胞活性試験やDNA損傷試験などの様々な試験および技術は、これらの化合物の生物活性を評価するために使用されている。
化学原料を購入する必要がある場合は、 要求情報を送信してください最新の見積りを入手してください。
体外試験の学術論文
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Structure-based design, synthesis and biological testing of etoposide analog epipodophyllotoxin-N-mustard hybrid compounds designed to covalently bind to topoisomerase II and DNA
関連化学物質
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4β-chloroacetamido-4-deoxy-4′-desmethylepipdophyllotoxin
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Design of potent and selective antagonists of the vasopressor responses to arginine-vasopressin
関連化学物質
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3-MERCAPTO-3-METHYL-BUTYRYL-TYR-PHE-VAL-ASN-CYS-PRO-D-ARG-GLY-NH2
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Discovery of novel dual functional agent as PPARγ agonist and 11β-HSD1 inhibitor for the treatment of diabetes
関連化学物質
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3-{4-[2-amino-6-(4-pyrimidin-2-ylpiperazin-1-yl)pyrimidin-4-yloxy]phenyl}-2-methyl-2-phenoxypropionic acid
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A study of anti-inflammatory and analgesic activity of new 2,4,6-trisubstituted pyrimidines
関連化学物質
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3-bromo-4'-amino-chalcone
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Design, synthesis, and evaluation of novel anti-trypanosomal compounds
関連化学物質
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N-(3-chlorobenzyl)-N-methylpiperidin-4-amine
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Synthesis of new substance P analogues releasing histamine from rat peritoneal mast cells
関連化学物質
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Boc-Pro-Lys(Z)-Pro-OCH3
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Structure-based design of 5-Methylpyrimidopyridone derivatives as new wild-type sparing inhibitors of the epidermal growth factor receptor triple mutant (EGFRL858R/T790M/C797S)
関連化学物質
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tert-butyl (S)-3-((5-bromo-2-chloropyrimidin-4-yl)amino)piperidine-1-carboxylate
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bis(benzonitrile)palladium(II) dichloride
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Development of 3,4-dihydroisoquinolin-1(2H)-one derivatives for the Positron Emission Tomography (PET) imaging of σ2 receptors
関連化学物質
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2-(3-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)propyl)-6,7-dimethoxy-3,4-dihydroisoquinolin-1(2H)-one
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Metallocene-based inhibitors of cancer-associated carbonic anhydrase enzymes IX and XII
関連化学物質
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4-(ジメチルアミノ)ピリジン
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AMINES
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4-(5-phenyl-1H-1,2,3-triazol-1-yl)benzenesulfonamide
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Design, synthesis and antifungal activity of novel fenfuram-diarylamine hybrids
関連化学物質
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N-(4-BroMo-phenyl)-benzene-1,2-diaMine
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Discovery of an in vivo chemical probe of the lysine methyltransferases G9a and GLP
関連化学物質
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Methyl 5-Methoxy-2-nitro-4-(3-(pyrrolidin-1-yl)propoxy)benzoate
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Trisubstituted imidazoles as mycobacterium tuberculosis glutamine synthetase inhibitors
関連化学物質
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2-ETHYNYL-6-METHOXYNAPHTHALENE 97
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Substituted Aminoacetamides as Novel Leads for Malaria Treatment
関連化学物質
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2-CHLORO-N-PYRAZIN-2-YLACETAMIDE
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New topoisomerases inhibitors: Synthesis of rutaecarpine derivatives and their inhibitory activity against topoisomerases
関連化学物質
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6-[(4-Chloro-phenyl)-hydrazono]-6,7,8,9-tetrahydro-11H-pyrido[2,1-b]quinazoline-11-one
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Synthesis and evaluation of novel benzimidazole derivatives as antimicrobial agents
関連化学物質
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N-(4-chloro-3-fluorophenyl)-2-(5-methoxy-1H-benzo[d]imidazol-2-ylthio)acetamide
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Camptothecin and minor-groove binder hybrid molecules: Synthesis, inhibition of topoisomerase I, and anticancer cytotoxicity in vitro
関連化学物質
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1H-Pyrrole-2-carboxylicacid,4-amino-1-(methoxymethyl)-,ethylester(9CI)
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Synthesis and biological evaluation of orally active matrix metaloproteinase inhibitors
関連化学物質
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(2R)-2-bromo-4-methylpentanoic acid t-butyl ester
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Development of prohibitin ligands against osteoporosis
関連化学物質
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4-isopropylbenzenesulfonyl azide
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Synthesis and antimalarial activity of 2-guanidino-4-oxoimidazoline derivatives
関連化学物質
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N-(3,4-dichlorophenyl)-N'-(1-methyl-4-oxo-4,5-dihydro-1H-imidazol-2-yl)guanidine
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Synthesis and biological evaluation of disulfides as anticancer agents with thioredoxin inhibition
関連化学物質
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ベンゼンチオール
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炭酸水素ナトリウム
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2-((4-chlorophenyl)disulfanyl)pyridine
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Synthesis, cleavage, and antifungal activity of a number of novel, water-soluble ester prodrugs of antifungal triazole CS-758
関連化学物質
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Acetic acid, hydroxy-, (4-methoxyphenyl)methyl ester
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Aromatase Inhibitors. Synthesis and Evaluation of Mammary Tumor Inhibiting Activity of 3-Alkylated 3-(4-Aminophenyl)piperidine-2,6-diones
関連化学物質
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2,6-Piperidinedione, 3-(4-aminophenyl)-3-methyl-
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Synthesis of selective inhibitors against V. cholerae sialidase and human cytosolic sialidase NEU2
関連化学物質
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methyl acetamido-2,6-anhydro-3,5-dideoxy-9-p-toluenesulfonyl-D-glycero-D-galactonon-2-enonate
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Synthesis and Biological Evaluation of New Combined α/β-Adrenergic Blockers
関連化学物質
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フマル酸
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1-(3-Methoxymethyl-4-oxiranylmethoxy-phenyl)-ethanone
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Synthesis of gibberellin derivatives with anti-tumor bioactivities
関連化学物質
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C26H23FO6
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Synthesis, and antitumor activity of some N1-(Coumarin-7-yl) amidrazones and related congeners
関連化学物質
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7-{2-[1-(4-(2-fluorophenyl)piperazin-1-yl)-2-oxopropylidene]hydrazinyl}-4-methyl-2H-chromen-2-one
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Evaluation of aminohydantoins as a novel class of antimalarial agents
関連化学物質
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3-cyclohexyl-2-imino-5,5-diphenylimidazolidin-4-one
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Design and synthesis of a novel class of thrombin inhibitors incorporating heterocyclic dipeptide surrogates
関連化学物質
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2-methyl-5-benzylsulfonylamino-6-oxo-1 6-dihydro-1-pyrimidinylacetic acid
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(2-QUINOXALINON-3-YL)GLYOXAL DERIVATIVES FROM L-ASCORBIC ACID
関連化学物質
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3-Methyl-benzoic acid [(2S,3S)-2,3,4-trihydroxy-1-(3-oxo-3,4-dihydro-quinoxalin-2-yl)-but-(Z)-ylidene]-hydrazide
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SOME 4-SUBSTITUTED 1-(3-PYRIDYLMETHYL)PIPERAZINES WITH ANTIHISTAMINE ACTIVITY
関連化学物質
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[4-(4-methoxyphenyl)piperazin-1-yl](pyridin-3-yl)methanone
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Anticonvulsant activity, crystal structures, and preliminary safety evaluation of N - trans -cinnamoyl derivatives of selected (un)modified aminoalkanols
関連化学物質
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(2E)-N-(1-hydroxy-2-methylpropan-2-yl)-3-phenylprop-2-enamide
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Synthesis and structure-activity relationships of novel 2',2'-difluoro analogues of docetaxel
関連化学物質
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7,10-bis-O-(2,2,2-trichloroethoxycarbonyl)-13-O-{3-(tert-butoxycarbonylamino)-3-[(1-tert-butoxycarbonyl)pyrrole-2-yl]-2,2-difluoropropionyl}-10-deacetylbaccatin III
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2-Acylamino-5-chlorobenzophenones with enhanced selectivity towards malaria parasites
関連化学物質
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N-(2-benzoyl-4-chlorophenyl)-2-(4-methyl-1-piperazinyl)-2-phenylacetamide
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HL 752: A potent and long-acting antispasmodic agent
関連化学物質
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4-(2-PIPERIDYLETHOXY)BENZOPHENONE
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Synthesis, characterization and antimicrobial evaluation of novel derivatives of isoniazid
関連化学物質
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N-(3-((diethylamino)methyl)-2-ethoxybenzylidene)isonicotinohydrazide
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Molecular design, synthesis, and hypoglycemic activity of a series of thiazolidine-2,4-diones
関連化学物質
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5-[4-(3-ethyl-3H-imidazo[4,5-b]pyridin-2-ylmethoxy)benzyl]-3-triphenylmethylthiazolidine-2,4-dione
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Synthesis and Pharmacological Evaluation of New Chemical Entities from Ibuprofen as Novel Analgesic Candidates
関連化学物質
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ETHYL (S)-(-)-2-((METHYLSULFONYL)OXY)-PROPIONATE, TECH., 90
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ETHYL MANDELATE
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Synthesis and biological evaluation of cinnamido linked pyrrolo[2,1-c][1,4]benzodiazepines as antimitotic agents
関連化学物質
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7-methoxy-8-{6-[2-methoxy-4-[(E)-3-morpholino-3-oxo-1-propenyl]phenoxy]hexyloxy}-(11aS)-1,2,3,11a-tetrahydro-5H-pyrrolo[2,1-c][1,4]benzodiazepin-5-one
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Identification of a potent small-molecule inhibitor of bacterial DNA repair that potentiates quinolone antibiotic activity in methicillin-resistant Staphylococcus aureus
関連化学物質
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2-(4-{[(3-fluorophenyl)amino]carbonothioyl}-1-piperazinyl)-8-ethyl-5-oxo-5,8-dihydropyrido[2,3-d]pyrimidine-6-carboxylic acid
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Synthesis and biological evaluation of novel tamoxifen analogues
関連化学物質
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N-(4-((4'-(benzyloxy)phenyl)(hydroxy)-methyl)phenyl)propionamide
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