生体テストでは
A.最も有望な化合物を選択して、動物モデル(例えば、げっ歯類、イヌまたは非ヒト霊長類動物)においてインビボ試験を行う。 化合物がAVPによる血管収縮を遮断する能力を評価すると同時に、それらの薬物動態および毒性も評価する。
化学原料を購入する必要がある場合は、 要求情報を送信してください最新の見積りを入手してください。
生体テストではの学術論文
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Design of potent and selective antagonists of the vasopressor responses to arginine-vasopressin
関連化学物質
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3-MERCAPTO-3-METHYL-BUTYRYL-TYR-PHE-VAL-ASN-CYS-PRO-D-ARG-GLY-NH2
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A study of anti-inflammatory and analgesic activity of new 2,4,6-trisubstituted pyrimidines
関連化学物質
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3-bromo-4'-amino-chalcone
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Design, synthesis, and evaluation of novel anti-trypanosomal compounds
関連化学物質
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N-(3-chlorobenzyl)-N-methylpiperidin-4-amine
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Development of 3,4-dihydroisoquinolin-1(2H)-one derivatives for the Positron Emission Tomography (PET) imaging of σ2 receptors
関連化学物質
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2-(3-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)propyl)-6,7-dimethoxy-3,4-dihydroisoquinolin-1(2H)-one
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New topoisomerases inhibitors: Synthesis of rutaecarpine derivatives and their inhibitory activity against topoisomerases
関連化学物質
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6-[(4-Chloro-phenyl)-hydrazono]-6,7,8,9-tetrahydro-11H-pyrido[2,1-b]quinazoline-11-one
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Discovery of an in vivo chemical probe of the lysine methyltransferases G9a and GLP
関連化学物質
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Methyl 5-Methoxy-2-nitro-4-(3-(pyrrolidin-1-yl)propoxy)benzoate
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CCR5 receptor antagonists: Discovery and SAR of novel 4-hydroxypiperidine derivatives
関連化学物質
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5-BROMO-2-[(4-CHLOROBENZYL)OXY]BENZALDEHYDE
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Development of prohibitin ligands against osteoporosis
関連化学物質
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4-isopropylbenzenesulfonyl azide
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Synthesis and antimalarial activity of 2-guanidino-4-oxoimidazoline derivatives
関連化学物質
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N-(3,4-dichlorophenyl)-N'-(1-methyl-4-oxo-4,5-dihydro-1H-imidazol-2-yl)guanidine
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Synthesis, and antitumor activity of some N1-(Coumarin-7-yl) amidrazones and related congeners
関連化学物質
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7-{2-[1-(4-(2-fluorophenyl)piperazin-1-yl)-2-oxopropylidene]hydrazinyl}-4-methyl-2H-chromen-2-one
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Substituted Aminoacetamides as Novel Leads for Malaria Treatment
関連化学物質
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2-CHLORO-N-PYRAZIN-2-YLACETAMIDE
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Synthesis, characterization and antimicrobial evaluation of novel derivatives of isoniazid
関連化学物質
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N-(3-((diethylamino)methyl)-2-ethoxybenzylidene)isonicotinohydrazide
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Molecular design, synthesis, and hypoglycemic activity of a series of thiazolidine-2,4-diones
関連化学物質
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5-[4-(3-ethyl-3H-imidazo[4,5-b]pyridin-2-ylmethoxy)benzyl]-3-triphenylmethylthiazolidine-2,4-dione
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Synthesis, cleavage, and antifungal activity of a number of novel, water-soluble ester prodrugs of antifungal triazole CS-758
関連化学物質
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Acetic acid, hydroxy-, (4-methoxyphenyl)methyl ester
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Synthesis and Pharmacological Evaluation of New Chemical Entities from Ibuprofen as Novel Analgesic Candidates
関連化学物質
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ETHYL (S)-(-)-2-((METHYLSULFONYL)OXY)-PROPIONATE, TECH., 90
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ETHYL MANDELATE
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Aromatase Inhibitors. Synthesis and Evaluation of Mammary Tumor Inhibiting Activity of 3-Alkylated 3-(4-Aminophenyl)piperidine-2,6-diones
関連化学物質
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2,6-Piperidinedione, 3-(4-aminophenyl)-3-methyl-
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Synthesis of selective inhibitors against V. cholerae sialidase and human cytosolic sialidase NEU2
関連化学物質
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methyl acetamido-2,6-anhydro-3,5-dideoxy-9-p-toluenesulfonyl-D-glycero-D-galactonon-2-enonate
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Synthesis and Biological Evaluation of New Combined α/β-Adrenergic Blockers
関連化学物質
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フマル酸
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1-(3-Methoxymethyl-4-oxiranylmethoxy-phenyl)-ethanone
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Identification of a potent small-molecule inhibitor of bacterial DNA repair that potentiates quinolone antibiotic activity in methicillin-resistant Staphylococcus aureus
関連化学物質
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2-(4-{[(3-fluorophenyl)amino]carbonothioyl}-1-piperazinyl)-8-ethyl-5-oxo-5,8-dihydropyrido[2,3-d]pyrimidine-6-carboxylic acid
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Design, synthesis, activity, and structure of a novel class of matrix metalloproteinase inhibitors containing a heterocyclic P'2-P'3 amide bond isostere
関連化学物質
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ACETIC ACID
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(R)-(+)-2-(α-(i-butyl)MethanaMine)-1H-benziMidazole, Min. 98% (R)-i-Bu-BIMAH
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Synthesis of gibberellin derivatives with anti-tumor bioactivities
関連化学物質
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C26H23FO6
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Synthesis, biological evaluation and molecular docking studies of novel quinazolinones as antitubercular and antimicrobial agents
関連化学物質
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2-methylsulfanyl-3-(4-chlorophenyl)-3H-quinazolin-4-one
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Evaluation of aminohydantoins as a novel class of antimalarial agents
関連化学物質
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3-cyclohexyl-2-imino-5,5-diphenylimidazolidin-4-one
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Design and synthesis of a novel class of thrombin inhibitors incorporating heterocyclic dipeptide surrogates
関連化学物質
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2-methyl-5-benzylsulfonylamino-6-oxo-1 6-dihydro-1-pyrimidinylacetic acid
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Design of 5-(3,5-di-tert-butyl-4-hydroxyphenyl)-1,3,4-thiadiazoles, - 1,3,4-oxadiazoles, and -1,2,4-triazoles as orally-active, nonulcerogenic antiinflammatory agents
関連化学物質
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2-Propenoyl chloride, 3-[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]-, (E)-
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Synthesis and pharmacological evaluation of carbamic acid 1-phenyl-3-(4-phenyl-piperazine-1-yl)-propyl ester derivatives as new analgesic agents
関連化学物質
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carbamic acid 1-phenyl-3-(4-phenyl-piperazin-1-yl)-propyl ester
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SOME 4-SUBSTITUTED 1-(3-PYRIDYLMETHYL)PIPERAZINES WITH ANTIHISTAMINE ACTIVITY
関連化学物質
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[4-(4-methoxyphenyl)piperazin-1-yl](pyridin-3-yl)methanone
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Synthesis of novel triazoles, tetrazine, thiadiazoles and their biological activities
関連化学物質
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サリチルアルデヒドフェニルヒドラゾン
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Diaryldiamines with dual inhibition of the histamine H3 receptor and the norepinephrine transporter and the efficacy of 4-(3-(methylamino)-1- phenylpropyl)-6-(2-(pyrrolidin-1-yl)ethoxy)naphthalen-1-ol in pain
関連化学物質
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N-methyl-3-phenyl-3-(6-(2-(pyrrolidin-1-yl)ethoxy)naphthalen-1-yloxy)propan-1-amine
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Synthesis and antitumor activity of lipid A analogs having a phosphonooxyethyl group with α- or β-configuration at position 1
関連化学物質
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2-(diphenylphosphonooxy)ethyl 2-deoxy-6-O-<2-deoxy-4-O-diphenylphosphono-3-O-<(R)-3-tetradecanoyloxytetradecanoyl>-6-O-(2,2,2-trichloroethoxycarbonyl)-2-(2,2,2-trichloroethoxycarbonylamino)-β-D-glucopyranosyl>-3-O-tetradecanoyl-2-tetradecanoylamino...
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Imidazo[4,5-c]quinolines as inhibitors of the PI3K/PKB-pathway
関連化学物質
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2-(4-Aminophenyl)-2-methylpropanenitrile
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Identification of (3R)-7-hydroxy-N-((1S)-1-{[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1- piperidinyl]methyl}-2-methylpropyl)-1,2,3,4-tetrahydro-3- isoquinolinecarboxamide as a novel potent and selective opioid κ receptor antagonist
関連化学物質
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(3R)-4-(3-isopropoxyphenyl)-1,3,4-triMethylpiperidine
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Synthesis and structure-activity relationships of novel 2',2'-difluoro analogues of docetaxel
関連化学物質
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7,10-bis-O-(2,2,2-trichloroethoxycarbonyl)-13-O-{3-(tert-butoxycarbonylamino)-3-[(1-tert-butoxycarbonyl)pyrrole-2-yl]-2,2-difluoropropionyl}-10-deacetylbaccatin III
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Synthesis of imidazothiazole-chalcone derivatives as anticancer and apoptosis inducing agents
関連化学物質
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(E)-3-(6-(4-methoxyphenyl)imidazo[2,1-b]thiazol-5-yl)-1-(3,4,5-trimethoxyphenyl)prop-2-en-1-one
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Bifunctional acyclic nucleoside phosphonates: 2. Symmetrical 2-{[bis(phosphono)methoxy]methyl}ethyl derivatives of purines and pyrimidines
関連化学物質
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5-[(benzyloxy)methyl]-2,2-dimethyl-1,3-dioxane
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Arylamidrazones as novel corticotropin releasing factor receptor antagonists
関連化学物質
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C10H8BrF3N2O
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Novel orally active NPY Y5 receptor antagonists: Synthesis and structure-activity relationship of spiroindoline class compounds
関連化学物質
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(6-chloro-pyridin-3-yl)-carbamic acid phenyl ester
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