販売手がかり最適化
生物と安全性評価結果に基づき，先導化合物の精製と最適化を継続した。
化学原料を購入する必要がある場合は、 要求情報を送信してください最新の見積りを入手してください。
販売手がかり最適化の学術論文
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Synthesis of PPAR-γ activators inspired by the marine natural product, paecilocin A
関連化学物質
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3-ethoxy-N-(p-ethoxy-phenethyl) phthalimide
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Discovery of biphenylacetamide-derived inhibitors of BACE1 using de novo structure-based molecular design
関連化学物質
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2-([1,1'-biphenyl]-4-yl)-N-(4-methoxybenzyl)acetamide
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Structure-based design of caspase-1 inhibitor containing a diphenyl ether sulfonamide
関連化学物質
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2-(4-isopropyl-3-methyl-phenoxy)-phenylamine
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Design, synthesis, antimycobacterial evaluation, and in silico studies of 3-(phenylcarbamoyl)-pyrazine-2-carboxylic acids
関連化学物質
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3-(anilinocarbonyl)-2-pyrazinecarboxylic acid
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Synthesis and evaluation of α-thymidine analogues as novel antimalarials
関連化学物質
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5'-deoxy-5'-(4-nitrobenzamido)thymidine
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Design and synthesis of thrombin receptor-derived nonpeptide mimetics utilizing a piperazine scaffold
関連化学物質
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1-phenylacetyl-4-[2-(tert-butoxycarbonylamino)acetyl]piperazine
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Synthesis and Evaluation of Non-peptidic Cysteine Protease Inhibitors of P. falciparum Derived from Etacrynic Acid
関連化学物質
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6-{2-[2,3-dichloro-4-(2-methylenebutyryl)phenoxy]acetylamino}hexanoic acid
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Synthesis and biological evaluation of 3,5-disubstituted-4-alkynylisoxozales as a novel class of HSP90 inhibitors
関連化学物質
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ethyl-5-(2,4-dibenzyloxy-5-isopropylphenyl)-4-iodoisoxazole-3-carboxylate
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From cycloheptathiophene-3-carboxamide to oxazinone-based derivatives as allosteric HIV-1 ribonuclease H inhibitors
関連化学物質
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2-phenyl-6,7,8,9-tetrahydro-4H,5H-cyclohepta[4,5]thieno[2,3-d][1,3]oxazin-4-one
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Discovery of a novel small molecule agonist scaffold for the APJ receptor
関連化学物質
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(2S)-cyclohexyl({[5-(2,6-dimethoxyphenyl)-1-(4-fluorophenyl)-1H-pyrazol-3-yl]carbonyl}amino)ethanoic acid
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Synthesis and pharmacological characterization of novel 6-fluorochroman derivatives as potential 5-HT(1A) receptor antagonists
関連化学物質
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2-[4-(4-Ethoxy-phenyl)-butyl]-isoindole-1,3-dione
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Synthesis of arylidene-substituted gelastatin analogues and their screening for MMP-2 inhibitory activity
関連化学物質
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トリエチルアミン
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methyl acrylate
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9-BBN
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Design, synthesis, and biological evaluation of a potent, PKC selective, B-ring analog of bryostatin
関連化学物質
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{(S)-3-Benzyloxy-1-[(2S,6R)-6-((R)-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl)-tetrahydro-pyran-2-ylmethyl]-propoxy}-tert-butyl-diphenyl-silane
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Synthesis of thio-heterocyclic analogues from Baylis-Hillman bromides as potent cyclooxygenase-2 inhibitors
関連化学物質
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(Z)-2-Bromomethyl-3-(3-chloro-phenyl)-acrylic acid ethyl ester
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Design, synthesis and characterization of N9/N7-substituted 6-aminopurines as VEGF-R and EGF-R inhibitors
関連化学物質
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Ethanone, 2-(6-amino-9H-purin-9-yl)-1-phenyl-
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Identification of arginine analogues as antagonists and agonists for the melanocortin-4 receptor
関連化学物質
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(S)-2-TERT-BUTOXYCARBONYLAMINO-3-NAPHTHALEN-2-YL-PROPIONIC ACID METHYL ESTER
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Synthesis, molecular modeling and BACE-1 inhibitory study of tetrahydrobenzo[b] pyran derivatives
関連化学物質
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2-amino-4-(4-fluorophenyl)-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile
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CCR5 receptor antagonists: Discovery and SAR of novel 4-hydroxypiperidine derivatives
関連化学物質
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5-BROMO-2-[(4-CHLOROBENZYL)OXY]BENZALDEHYDE
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Design, synthesis, and anti-tumor evaluation of novel symmetrical bis-benzimidazoles
関連化学物質
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2,2'-di-[[(3-methyl-4-methoxy)pyridin-2-yl]methylenethio]-5,5'-bis-1H,1'H-benzimidazole
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Design, synthesis and SAR study of 2-aminopyrimidines with diverse Michael addition acceptors for chemically tuning the potency against EGFRL858R/T790M
関連化学物質
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1-(4-(3-Methoxy-4-nitrophenyl)piperazin-1-yl)ethanone
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Synthesis and Evaluation of Dolastatin 10 Analogues Containing Heteroatoms on the Amino Acid Side Chains
関連化学物質
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1-Pyrrolidinecarboxylic acid, 2-[(1R,2R)-1-methoxy-2-methyl-3-oxo-3-[(2-phenylethyl)amino]propyl]-, 1,1-dimethylethyl ester, (2S)-
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Parallel synthesis of DAPT derivatives and their γ-secretase- inhibitory activity
関連化学物質
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Glycine, N-[(3,5-difluorophenyl)acetyl]-L-alanyl-2-phenyl-, (2S)-
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Identification and SAR of squarate inhibitors of mitogen activated protein kinase-activated protein kinase 2 (MK-2)
関連化学物質
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3-{[(1S)-1-phenylethyl]amino}-4-(pyridin-4-ylamino)cyclobut-3-ene-1,2-dione
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Development and large-scale preparation of an oral TACE inhibitor
関連化学物質
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Benzeneacetic acid, a-aMino-4-hydroxy-, ethyl ester, (aR)-
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Synthesis and biological evaluation of a focused library of beauveriolides
関連化学物質
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C27H43N3O6*ClH
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Imidazo[1,2-a]pyridines that directly interact with hepatitis C NS4B: Initial preclinical characterization
関連化学物質
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(3-chloro-6-furan-3-yl-8-trifluoromethyl-imidazo[1,2-a]pyridin-2-yl)-[3-(2-fluoro-phenyl)-pyrrolidin-1-yl]-methanone
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Development of Kinase Inactive PD173955 Analogues for Reducing Production of Aβ Peptides
関連化学物質
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6-(2,6-DICHLOROPHENYL)-8-METHYL-2-METHYLSULFONYL-8H-PYRIDO[2,3-D]PYRIMIDIN-7-ONE
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Design, synthesis and anticancer activities of hybrids of indole and barbituric acids-Identification of highly promising leads
関連化学物質
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バルビツール酸
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C22H19N3O5S
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INDOLE-3-CARBOXALDEHYDE
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Synthesis of selective inhibitors against V. cholerae sialidase and human cytosolic sialidase NEU2
関連化学物質
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methyl acetamido-2,6-anhydro-3,5-dideoxy-9-p-toluenesulfonyl-D-glycero-D-galactonon-2-enonate
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New potential biologically active compounds: Design and an efficient synthesis of N-substituted 4-aryl-4,6,7,8-tetrahydroquinoline-2,5(1H,3H)-diones under microwave irradiation
関連化学物質
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2,5(1H,3H)-Quinolinedione, 4,6,7,8-tetrahydro-4-(4-methoxyphenyl)-1,7,7-trimethyl-
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Identification of a potent small-molecule inhibitor of bacterial DNA repair that potentiates quinolone antibiotic activity in methicillin-resistant Staphylococcus aureus
関連化学物質
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2-(4-{[(3-fluorophenyl)amino]carbonothioyl}-1-piperazinyl)-8-ethyl-5-oxo-5,8-dihydropyrido[2,3-d]pyrimidine-6-carboxylic acid
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Design and synthesis of phenylisoxazole derivatives as novel human acrosin inhibitors
関連化学物質
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HCl
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ethyl 5-(4-(4-fluorobenzamido)phenyl)isoxazole-3-carboxylate
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Pd-mediated functionalization of polysubstituted pyrroles: Their evaluation as potential inhibitors of PDE4
関連化学物質
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ethyl 2-benzoyl-5-phenyl-1-(4-(phenylethynyl)phenyl)-1H-pyrrole-3-carboxylate
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Investigation of subsite preferences in aminopeptidase A (EC 3.4.11.7) led to the design of the first highly potent and selective inhibitors of this enzyme
関連化学物質
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(2S,3S), 2-[4-methoxybenzylsulfanyl], 3-tertiobutyloxycarbonylamino-hexane-dioic acid 1-allyl ester, 6-tertiobutyl ester
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trifluoroacetic acid
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Design and synthesis of an orally active GPIIb/IIIa antagonist based on a phenylpiperazine scaffold
関連化学物質
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塩化ベンゼン
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tert-Butyl 3-{4-[4-(4-amidinophenyl)-1-piperazinyl]phenyl}propionate
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Molecular design, synthesis and biological evaluation of BP-O-DAPY and O-DAPY derivatives as non-nucleoside HIV-1 reverse transcriptase inhibitors
関連化学物質
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エチレンジアミンテトラ酢酸
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Picogreen
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4-{4-[2-benzoyl-5-methoxyphenoxy]pyrimidin-2-ylamino}benzonitrile
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Imidazolopiperazines: Lead optimization of the second-generation antimalarial agents
関連化学物質
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2-(4-fluorophenyl)-3-(p-tolylamino)-7,8-dihydroimidazo[1,2-a]pyrazin-6(5H)-one
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Utilization of halogen bond in lead optimization: A case study of rational design of potent phosphodiesterase type 5 (PDE5) inhibitors
関連化学物質
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6-ethyl-2-[2-propoxy-5-(4-methyl-1-piperazinylsulfonyl)-phenyl]pyrimidin-4(3H)-one
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Inhibition of the tissue factor/factor VIIa complex - Lead optimisation using combinatorial chemistry
関連化学物質
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Acetic acid, [4-[[[(4-nitrophenoxy)carbonyl]oxy]methyl]phenoxy]-, 2-propenyl ester
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Lead optimization of n-3-substituted 7-morpholinotriazolopyrimidines as dual phosphoinositide 3-kinase/mammalian target of rapamycin inhibitors: Discovery of PKI-402
関連化学物質
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(1-benzylpiperidin-4-yl)-(2-chloro-6-morpholin-4-yl-5-nitropyrimidin-4-yl)amine
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