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構造効果関係(SAR)
複素環芳香族側鎖とその特定の置換基の選択は抗菌性能に影響する。抗菌活性と選択性を増強するために様々な構造修飾を探索した。
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構造効果関係(SAR)の学術論文
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Synthesis and Antibacterial Activities of 4-Pyrrolidinylthio Carbapenems: Containing Heteroaromatics as a Side Chain
関連化学物質
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(4R,5S,6S)-3-((3S,5S)-1-Allyloxycarbonyl-5-imidazol-1-ylmethyl-pyrrolidin-3-ylsulfanyl)-6-((R)-1-hydroxy-ethyl)-4-methyl-7-oxo-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid allyl ester
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Synthesis, properties, and pharmacokinetic studies of N2-phenylguanine derivatives as inhibitors of herpes simplex virus thymidine kinases
関連化学物質
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6H-Purin-6-one, 1,9-dihydro-9-(4-hydroxybutyl)-2-(phenylamino)-
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2-Bromohypoxanthine
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Synthesis and antifungal activity of substituted-10-methyl-1,2,3,4- tetrahydropyrazino[1,2-a]indoles
関連化学物質
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Pyrazino[1,2-a]indole, 1,2,3,4-tetrahydro-10-methyl-1-phenyl-
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Structure-activity, theoretical, and X-ray studies on the intramolecular interactions in a series of novel histamine H2 receptor antagonists
関連化学物質
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2-[[3-(N,N-Dimethylaminomethyl)phenyl]methylthio]ethanamine
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Synthesis and Evaluation of Non-peptidic Cysteine Protease Inhibitors of P. falciparum Derived from Etacrynic Acid
関連化学物質
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6-{2-[2,3-dichloro-4-(2-methylenebutyryl)phenoxy]acetylamino}hexanoic acid
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Tariquidar-related triazoles as potent, selective and stable inhibitors of ABCG2 (BCRP)
関連化学物質
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1-(2-amino-4-bromophenyl)ethanone
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TVB-2640
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topotecan
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Hydrazine derivatives and o-benzoylbenzoic acid as a source of phthalazines with their antimicrobial activities
関連化学物質
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1(2H)-Phthalazinethione, 2,4-diphenyl-
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Benzylamine Antioxidants: Relationship between Structure, Peroxyl Radical Scavenging, Lipid Peroxidation Inhibition, and Cytoprotection
関連化学物質
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4-[(butylamino)methyl]-2,6-dimethoxyphenol
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Identification of 4-anilino-6-aminoquinazoline derivatives as potential MERS-CoV inhibitors
関連化学物質
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6-Amino-4-(3-chloro-4-fluoroanilino)quinazoline
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ガソリン（オクタン価５０－１００）
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Synthesis and cytotoxic evaluation of a series of γ-substituted γ-aryloxymethyl-α-methylene-γ-butyrolactones against cancer cells
関連化学物質
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1-(4-fluorophenyl)-2-(2-naphthyloxy)ethanone
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Synthesis and SAR of 6-substituted purine derivatives as novel selective positive inotropes
関連化学物質
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1-(1-chloro-2-hydroxy-3-propanyl)-4-[bis(4-fluorophenyl)-methyl]-piperazine
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1,3,4-Oxadiazole-3(2H)-carboxamide derivatives as potential novel class of monoamine oxidase (MAO) inhibitors: Synthesis, evaluation, and role of urea moiety
関連化学物質
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5-(benzo[d][1,3]dioxol-5-yl)-2,2-dibutyl-N-(2-chlorobenzoyl)-1,3,4-oxadiazole-3(2H)-carboxamide
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Synthesis and evaluation of
aseries of homologues of lobelane at the vesicular monoamine transporter-2関連化学物質
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2-phenyl-6-(3-phenylpropyl)pyridine
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CCR5 receptor antagonists: Discovery and SAR of novel 4-hydroxypiperidine derivatives
関連化学物質
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5-BROMO-2-[(4-CHLOROBENZYL)OXY]BENZALDEHYDE
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Structure-activity relationship and in vitro and in vivo evaluation of the potent cytotoxic anti-microtubule agent N-(4-methoxyphenyl)-N,2,6-trimethyl-6,7- dihydro-5H-cyclopenta[d]pyrimidin-4-aminium chloride and its analogues as antitumor agents
関連化学物質
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7-METHYLINDOLE-3-ACETONITRILE
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Guanidine carbonate
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ammonium formate
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Synthesis and antimalarial activity of 2-guanidino-4-oxoimidazoline derivatives
関連化学物質
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N-(3,4-dichlorophenyl)-N'-(1-methyl-4-oxo-4,5-dihydro-1H-imidazol-2-yl)guanidine
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Synthesis and pharmacological screening of several aroyl and heteroaroyl selenylacetic acid derivatives as cytotoxic and antiproliferative agents
関連化学物質
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(4-tert-butylbenzoylselenyl)acetic acid
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Structure-activity relationship-guided development of retinoic acid receptor-related orphan receptor gamma (RORγ)-selective inverse agonists with a phenanthridin-6(5H)-one skeleton from a liver X receptor ligand
関連化学物質
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2-(4-butylamino-3-methoxyphenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol
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Dibenzylideneacetone analogues as novel Plasmodium falciparum inhibitors
関連化学物質
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C23H18F2N2
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Synthesis and evaluation of 2′,4′,6′-trihydroxychalcones as a new class of tyrosinase inhibitors
関連化学物質
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4H-1-Benzopyran-4-one, 2-(2,4-dihydroxyphenyl)-2,3-dihydro-5,7-dihydroxy-
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A matrix-focused structure-activity and binding site flexibility study of quinolinol inhibitors of botulinum neurotoxin serotype A
関連化学物質
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7-[(2-FLUOROPHENYL)(PYRIDIN-2-YLAMINO)METHYL]QUINOLIN-8-OL
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Synthesis and cytotoxicity studies of novel [1,2,4] Triazolo [1,5-a]pyrimidine-7-amines
関連化学物質
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N-(3-chlorophenyl)-5-methyl-2-(3-((5-(morpholinomethyl)furan-2-yl)methylthio)propyl)-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
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TVB-2640
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Synthesis and Antiviral Activity of Phosphonoacetic and Phosphonoformic Acid Esters of 5-Bromo-2'-deoxyuridine and Related Pyrimidine Nucleosides and Acyclonucleosides
関連化学物質
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Sodium; {[(2R,3S,5R)-5-(2,4-dioxo-5-vinyl-3,4-dihydro-2H-pyrimidin-1-yl)-3-hydroxy-tetrahydro-furan-2-ylmethoxy]-hydroxy-phosphoryl}-acetate
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Synthesis and biological evaluation of penam sulfones as inhibitors of β-lactamases
関連化学物質
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benzhydryl 2β-(chloroacetoxy)methyl-1,1-dioxo-penicillanate
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2,6-Disubstituted imidazo[2,1-b][1,3,4]thiadiazoles: Search for anticancer agents
関連化学物質
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2-(2-fluorobiphenyl-4-yl)-6-phenylimidazo[2,1-b][1,3,4]thiadiazole
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Design and synthesis of a novel class of thrombin inhibitors incorporating heterocyclic dipeptide surrogates
関連化学物質
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2-methyl-5-benzylsulfonylamino-6-oxo-1 6-dihydro-1-pyrimidinylacetic acid
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Development of Small Molecules with a Noncanonical Binding Mode to HIV-1 Trans Activation Response (TAR) RNA
関連化学物質
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3-amino-6-methyl-N-(3-(trifluoromethyl)phenyl)thieno[2,3-b]pyridine-2-carboxamide
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Pyrazolo[1,5-a]pyrimidine-based inhibitors of HCV polymerase
関連化学物質
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C23H27NO2S
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Novel indole-based peroxisome proliferator-activated receptor agonists: Design, SAR, structural biology, and biological activities
関連化学物質
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2-[4-(allyloxy)-2-hydroxyphenyl]-1-phenyl-1-ethanone
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Further explorations on bridged 1,2,4-trioxanes
関連化学物質
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5-[5-(tert-butyl-dimethyl-silanyloxy)-pentane-1-sulfonyl]-1-phenyl-1H-tetrazole
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Studies on the Insecticidal Activities of Some New N-Benzoyl-N'-Arylureas
関連化学物質
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(4-Aminophenyl)(4-fluorophenyl)methanone
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Approaches to the high-throughput synthesis of analogues of dihydroaertiginoic acid
関連化学物質
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L-Cysteine, N-(2-hydroxybenzoyl)-
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Synthesis of piplartine analogs and preliminary findings on structure–antimicrobial activity relationship
関連化学物質
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(E)-N′-cinnamoylbenzohydrazide
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Studies on coumarins, II
関連化学物質
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6-Methyl-4-phenoxymethyl-chromen-2-one
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Small-molecular, non-peptide, non-ATP-competitive polo-like kinase 1 (Plk1) inhibitors with a terphenyl skeleton
関連化学物質
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3,5-Difluoro-4-hydroxybenzeneboronic acid pinacol ester, 96%
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Design of cell-permeable stapled peptides as HIV-1 integrase inhibitors
関連化学物質
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C75H112N18O13
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Discovery of novel isothiazole inhibitors of the TrkA kinase: Structure-activity relationship, computer modeling, optimization, and identification of highly potent antagonists
関連化学物質
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(4-cyano-3-mercapto-isothiazol-5-yl)-carbamic acid phenyl ester
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Design synthesis and antibacterial activity studies of new thiadiazoloquinolone compounds
関連化学物質
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ethyl 2-[(2,4-dichloro-5-fluoro-3-nitrophenyl)carbonyl]-3-(dimethylamino)prop-2-enoate
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"Vinylogs" and "acetylenylogs" of β-adrenergic agents
関連化学物質
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2-<2'-(trifluoromethyl)phenyl>ethen-1-yl-oxirane
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Synthesis, anti-Toxoplasma gondii and antimicrobial activities of benzaldehyde 4-phenyl-3-thiosemicarbazones and 2-[(phenylmethylene)hydrazono]-4-oxo-3-phenyl-5-thiazolidineacetic acids
関連化学物質
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(E)-2-(3,4-dichlorobenzylidene)-N-phenylhydrazinecarbothioamide
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Synthesis, anticandidal activity and cytotoxicity of some tetrazole derivatives
関連化学物質
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1-(4-fluorophenyl)-2-[(1-methyl-1H-tetraazol-5-yl)sulfanyl]ethanone
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