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構造効果関係(SAR)研究
一連の反復によって、研究者は、その効力および選択性を向上させるために、ハイブリッド化合物の化学構造を修正することができる。合成開口レーダー研究はこれらの分子の設計を改善し、その治療潜在力を増強することに役立つ。
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構造効果関係(SAR)研究の学術論文
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Structure-based design, synthesis and biological testing of etoposide analog epipodophyllotoxin-N-mustard hybrid compounds designed to covalently bind to topoisomerase II and DNA
関連化学物質
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4β-chloroacetamido-4-deoxy-4′-desmethylepipdophyllotoxin
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Synthesis and pharmacological testing of polyaminoquinolines as blockers of the apamin-sensitive Ca2+-activated K+ channel (SKCa)
関連化学物質
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4-(3-AMINOPROP-1-YL)AMINOQUINOLINE
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Synthesis of iodo-aryl-azido adenosine analogs as affinity ligands for adenylyl cyclase
関連化学物質
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(4-Amino-3-iodophenyl)acetic acid
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Synthesis of 4-alkyl-, 4-aryl- and 4-arylamino-5-aminoisoquinolin-1-ones and identification of a new PARP-2 selective inhibitor
関連化学物質
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1-methoxy-5-nitro-4-phenylisoquinoline
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Discovery of biphenylacetamide-derived inhibitors of BACE1 using de novo structure-based molecular design
関連化学物質
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2-([1,1'-biphenyl]-4-yl)-N-(4-methoxybenzyl)acetamide
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Synthesis of new oxazolidine, oxazolidin-2-one and perhydro-1,4-oxazine derivatives of arylethanolamine as potential beta3-adrenoceptor agonists
関連化学物質
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3-tert-butyl-5-[(3,4-dihydro-2H-thiochromen-8-yloxy)methyl]-1,3-oxazolidin-2-one
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Synthesis and biological evaluation of the pyrazole class of cyclooxygenase-2-inhibitors
関連化学物質
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3-(4-chlorophenyl)-1-(4-nitrophenyl)-1H-pyrazole-4-carbaldehyde
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Synthesis and biology of the rigidified glutamate analogue, trans-2-carboxyazetidine-3-acetic acid (t-CAA)
関連化学物質
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(2R,3R)-3-Allyl-azetidine-1,2-dicarboxylic acid 1-benzyl ester
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Synthesis of novel structurally simplified estrogen analogues
関連化学物質
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3-(2-chloro-4-hydroxyphenylethynyl)-2-methylcyclohex-2-enone
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Design and synthesis of new transition-state analogue inhibitors of aspartate transcarbamylase
関連化学物質
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dibenzyl N-(phosphonoacetyl)aspartate
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Synthesis and phosphodiesterase 5 inhibitory activity of new 5-phenyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one derivatives containing an N-acylamido group on a phenyl ring
関連化学物質
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1-Methyl-5-(5-nitro-2-propoxyphenyl)-3-propyl-1,4-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one
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Synthesis and antibacterial activity of some heterocyclic chalcone analogues alone and in combination with antibiotics
関連化学物質
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3-(3,4-dimethoxyphenyl)-1-(furan-2-yl)prop-2-en-1-one
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Synthesis and evaluation of α-thymidine analogues as novel antimalarials
関連化学物質
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5'-deoxy-5'-(4-nitrobenzamido)thymidine
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Synthesis and biological evaluation of 3,5-disubstituted-4-alkynylisoxozales as a novel class of HSP90 inhibitors
関連化学物質
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ethyl-5-(2,4-dibenzyloxy-5-isopropylphenyl)-4-iodoisoxazole-3-carboxylate
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From cycloheptathiophene-3-carboxamide to oxazinone-based derivatives as allosteric HIV-1 ribonuclease H inhibitors
関連化学物質
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2-phenyl-6,7,8,9-tetrahydro-4H,5H-cyclohepta[4,5]thieno[2,3-d][1,3]oxazin-4-one
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Synthesis of potential inhibitors of hemagglutination by influenza virus: Chemoenzymic preparation of N-5 analogs of N-acetylneuraminic acid
関連化学物質
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5-N-carbobenzoxylamino-3,5-dideoxy-β-D-glycero-D-galacto-2-nonulopyranosidonic acid methyl ester
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SYNTHESIS AND STUDY OF THE ANTIVIRAL ACTIVITY OF PROPANOLAMINE DERIVATIVES
関連化学物質
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Benzamide, N-(2-hydroxy-3-phenoxypropyl)-4-nitro-
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Discovery of a novel small molecule agonist scaffold for the APJ receptor
関連化学物質
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(2S)-cyclohexyl({[5-(2,6-dimethoxyphenyl)-1-(4-fluorophenyl)-1H-pyrazol-3-yl]carbonyl}amino)ethanoic acid
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Carbonic anhydrase inhibitors - Part 49: Synthesis of substituted ureido and thioureido derivatives of aromatic/heterocyclic sulfonamides with increased affinities for isozyme I
関連化学物質
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Benzenesulfonamide, 4-[2-[[(2-propenylamino)thioxomethyl]amino]ethyl]-
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Synthesis of new substance P analogues releasing histamine from rat peritoneal mast cells
関連化学物質
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Boc-Pro-Lys(Z)-Pro-OCH3
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)
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Design, synthesis, and antitumor activity-absolute configuration relationships of podophyllotoxin aza-analogues
関連化学物質
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2-aza-4'-demethyldeoxypodophyllotoxin
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An 'inside-out' approach to suramin analogues
関連化学物質
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N,N'-bis(3-aminophenyl)urea
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Potential antitumor agents. 54. Chromophore requirements for in vivo antitumor activity among the general class of linear tricyclic carboxamides
関連化学物質
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N-[2-(dimethylamino)ethyl]phenazine-1-carboxamide
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4-Aminoquinoline-chalcone/-N-acetylpyrazoline conjugates: Synthesis and antiplasmodial evaluation
関連化学物質
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3-(4-methoxy-phenyl)-1-(4-prop-2-ynyloxy-phenyl)-propenone
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Synthesis and pharmacological characterization of novel 6-fluorochroman derivatives as potential 5-HT(1A) receptor antagonists
関連化学物質
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2-[4-(4-Ethoxy-phenyl)-butyl]-isoindole-1,3-dione
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Synthesis and biological evaluation of piperic acid amides as free radical scavengers and αglucosidase inhibitors
関連化学物質
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(2E,4E)-5-(1,3-benzodioxol-5-yl)-N-(3-phenylpropyl)-2,4-pentadienamide
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Senolytic activity of piperlongumine analogues: Synthesis and biological evaluation
関連化学物質
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trans-cinnamic pivalic anhydride
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Synthesis and in vitro antibacterial activity of catechol-spiramycin conjugates
関連化学物質
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6-(2,3-dihydroxy-benzoylamino)-hexanoic acid benzyl ester
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Identification of a series of highly potent activators of the Nurr1 signaling pathway
関連化学物質
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4-[(2-methoxyethoxy)methyl]benzoic acid
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Design, synthesis and characterization of N9/N7-substituted 6-aminopurines as VEGF-R and EGF-R inhibitors
関連化学物質
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Ethanone, 2-(6-amino-9H-purin-9-yl)-1-phenyl-
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Synthesis of new class of spirocarbocycle derivatives by multicomponent domino reaction and their evaluation for antimicrobial, anticancer activity and molecular docking studies
関連化学物質
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2-(4-methoxybenzylidene)cyclohexane-1,3-dione
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Molecular modeling of drug-pathophysiological Mtb protein targets: Synthesis of some 2-thioxo-1, 3-thiazolidin-4-one derivatives as anti-tubercular agents
関連化学物質
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(Z)-5-(4-benzyloxyphenyl)methylidene-2-thioxo-4-thiazolidinone
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Synthesis and cytotoxicity of bidesmosidic betulin and betulinic acid saponins
関連化学物質
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betulin 3β-O-2,3,4-tri-O-benzoyl-α-L-arabinopyranoside
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Studies on the synthesis of nicotinamide nucleoside and nucleotide analogues and their inhibitions towards CD38 nadase
関連化学物質
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((3aR,5R,6S,6aS)-6-fluoro-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)methyl benzoate
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Design, synthesis, and anti-tumor evaluation of novel symmetrical bis-benzimidazoles
関連化学物質
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2,2'-di-[[(3-methyl-4-methoxy)pyridin-2-yl]methylenethio]-5,5'-bis-1H,1'H-benzimidazole
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Synthesis and antiviral activity of 5-substituted cytidine analogues: Identification of a potent inhibitor of viral RNA-dependent RNA polymerases
関連化学物質
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2-((benzoyloxy)methyl)-5-(4,5-diamino-2-oxopyrimidin-1(2H)yl)tetrahydrofuran-3,4-diyl dibenzoate
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Synthesis and Evaluation of Dolastatin 10 Analogues Containing Heteroatoms on the Amino Acid Side Chains
関連化学物質
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1-Pyrrolidinecarboxylic acid, 2-[(1R,2R)-1-methoxy-2-methyl-3-oxo-3-[(2-phenylethyl)amino]propyl]-, 1,1-dimethylethyl ester, (2S)-
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Selective inhibitory activity against MAO and molecular modeling studies of 2-thiazolylhydrazone derivatives
関連化学物質
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2-BENZYLIDENEHYDRAZINE-1-CARBOTHIOAMIDE
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THIOSEMICARBAZIDE
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Synthesis and biological evaluation of disulfides as anticancer agents with thioredoxin inhibition
関連化学物質
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2-((4-chlorophenyl)disulfanyl)pyridine
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Thiophenol
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Iodine
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Improved, selective, human intestinal carboxylesterase inhibitors designed to modulate 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin (irinotecan; CPT-11) toxicity
関連化学物質
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N,N'-(1,4-phenylene)bis(2-fluorobenzenesulfonamide)
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ピリジン
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