臨床試験
化合物が臨床前研究において顕著な将来性を示す場合、ヒト患者における安全性および有効性を評価するために臨床試験に入る可能性がある。臨床試験は多くの段階に関連しており，厳しい試験により癌治療としての有効性を確保している。
化学原料を購入する必要がある場合は、 要求情報を送信してください最新の見積りを入手してください。
臨床試験の学術論文
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Structure-based design, synthesis and biological testing of etoposide analog epipodophyllotoxin-N-mustard hybrid compounds designed to covalently bind to topoisomerase II and DNA
関連化学物質
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4β-chloroacetamido-4-deoxy-4′-desmethylepipdophyllotoxin
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Design, Synthesis, and Biological Evaluation of Tetrahydro-β-carboline Derivatives as Selective Sub-Nanomolar Gelatinase Inhibitors
関連化学物質
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(1RS)-2-(4''-methoxy-4'-phenoxybenzenesulfonyl)-1,2,3,4-tetrahydro-norarmano-1-carboxylic acid
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Optimization of the anti-cancer activity of the phosphatidylinositol-3 kinase pathway inhibitor PITENIN-1: Switching thiourea with 1,2,3-triazole
関連化学物質
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(1-(5-chloro-2-methoxyphenyl)-1H-1,2,3-triazol-4-yl)(phenyl)methanone
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Pyridine analogues of nimesulide: Design, synthesis, and in vitro and in vivo pharmacological evaluation as promising cyclooxygenase 1 and 2 inhibitors
関連化学物質
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4-nitro-3-(3-bromophenylamino)pyridine N-oxide
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Synthesis and biological evaluation of the pyrazole class of cyclooxygenase-2-inhibitors
関連化学物質
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3-(4-chlorophenyl)-1-(4-nitrophenyl)-1H-pyrazole-4-carbaldehyde
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Discovery of novel dual functional agent as PPARγ agonist and 11β-HSD1 inhibitor for the treatment of diabetes
関連化学物質
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3-{4-[2-amino-6-(4-pyrimidin-2-ylpiperazin-1-yl)pyrimidin-4-yloxy]phenyl}-2-methyl-2-phenoxypropionic acid
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Synthesis of macrocyclic, potential inhibitors using a generic scaffold
関連化学物質
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2-benzyloxycarbonylamino-3-iodo-propionic acid tert-butyl ester
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Design and synthesis of new transition-state analogue inhibitors of aspartate transcarbamylase
関連化学物質
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dibenzyl N-(phosphonoacetyl)aspartate
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Synthesis and evaluation of α-thymidine analogues as novel antimalarials
関連化学物質
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5'-deoxy-5'-(4-nitrobenzamido)thymidine
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Identification of a novel fluoropyrrole derivative as a potassium-competitive acid blocker with long duration of action
関連化学物質
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1-[5-(2-Fluoropyridin-3-yl)-1-(phenylsulfonyl)-1H-pyrrol-3-yl]-N-methylmethanamine fumarate
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Synthesis and Evaluation of Non-peptidic Cysteine Protease Inhibitors of P. falciparum Derived from Etacrynic Acid
関連化学物質
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6-{2-[2,3-dichloro-4-(2-methylenebutyryl)phenoxy]acetylamino}hexanoic acid
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SYNTHESIS AND STUDY OF THE ANTIVIRAL ACTIVITY OF PROPANOLAMINE DERIVATIVES
関連化学物質
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Benzamide, N-(2-hydroxy-3-phenoxypropyl)-4-nitro-
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Identification of a potent and selective free fatty acid receptor 1 (FFA1/GPR40) agonist with favorable physicochemical and in vitro ADME properties
関連化学物質
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methyl 3-(4-((2-chloropyridin-4-yl)ethynyl)phenyl)propanoate
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Preparation and anti-inflammatory activities of diarylheptanoid and diarylheptylamine analogs
関連化学物質
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3-Heptanone, 1,7-bis(4-hydroxy-3-methoxyphenyl)-
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Synthesis and Biological Activity of the Four Stereoisomers of 6-<4-<3-<<2-Hydroxy-3-<4-<2-(cyclopropylmethoxy)ethyl>phenoxy>propyl>amino>propionamido>phenyl>-5-methyl-4,5-dihydro-3(2H)-pyridazinone, a Combined Vasodilator and β-Adrenoceptor Antagonist
関連化学物質
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シリカゲル
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2-Propanol, 1-amino-3-[4-[2-(cyclopropylmethoxy)ethyl]phenoxy]-, (S)-
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Synthesis and pharmacological characterization of novel 6-fluorochroman derivatives as potential 5-HT(1A) receptor antagonists
関連化学物質
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2-[4-(4-Ethoxy-phenyl)-butyl]-isoindole-1,3-dione
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Development of 3,4-dihydroisoquinolin-1(2H)-one derivatives for the Positron Emission Tomography (PET) imaging of σ2 receptors
関連化学物質
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2-(3-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)propyl)-6,7-dimethoxy-3,4-dihydroisoquinolin-1(2H)-one
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Preparation of phosphonooxymethyl prodrugs of HIV-1 attachment inhibitors
関連化学物質
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{3-[(4-benzoylpiperazin-1-yl)(oxo)acetyl]-4,7-dimethoxy-1H-pyrrolo[2,3-c]pyridin-1-yl}methyl dihydrogen phosphate
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New topoisomerases inhibitors: Synthesis of rutaecarpine derivatives and their inhibitory activity against topoisomerases
関連化学物質
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6-[(4-Chloro-phenyl)-hydrazono]-6,7,8,9-tetrahydro-11H-pyrido[2,1-b]quinazoline-11-one
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Design, synthesis and characterization of N9/N7-substituted 6-aminopurines as VEGF-R and EGF-R inhibitors
関連化学物質
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Ethanone, 2-(6-amino-9H-purin-9-yl)-1-phenyl-
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Metallocene-based inhibitors of cancer-associated carbonic anhydrase enzymes IX and XII
関連化学物質
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4-(ジメチルアミノ)ピリジン
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AMINES
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4-(5-phenyl-1H-1,2,3-triazol-1-yl)benzenesulfonamide
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Novel benzofuran derivatives for PET imaging of β-amyloid plaques in Alzheimer's disease brains
関連化学物質
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2-(4'-nitrophenyl)-5-methoxybenzo[b]furan
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Development of new LXR modulators that regulate LXR target genes and reduce lipogenesis in human cell models
関連化学物質
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12
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4-(bromomethyl)-N-cyclohexyl-N-methylbenzenesulfonamide
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Identification of arginine analogues as antagonists and agonists for the melanocortin-4 receptor
関連化学物質
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(S)-2-TERT-BUTOXYCARBONYLAMINO-3-NAPHTHALEN-2-YL-PROPIONIC ACID METHYL ESTER
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Synthesis and biological evaluation of orally active matrix metaloproteinase inhibitors
関連化学物質
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(2R)-2-bromo-4-methylpentanoic acid t-butyl ester
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Synthesis and antiviral activity of 5-substituted cytidine analogues: Identification of a potent inhibitor of viral RNA-dependent RNA polymerases
関連化学物質
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2-((benzoyloxy)methyl)-5-(4,5-diamino-2-oxopyrimidin-1(2H)yl)tetrahydrofuran-3,4-diyl dibenzoate
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Design, synthesis and SAR study of 2-aminopyrimidines with diverse Michael addition acceptors for chemically tuning the potency against EGFRL858R/T790M
関連化学物質
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1-(4-(3-Methoxy-4-nitrophenyl)piperazin-1-yl)ethanone
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Development of prohibitin ligands against osteoporosis
関連化学物質
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4-isopropylbenzenesulfonyl azide
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Parallel synthesis of DAPT derivatives and their γ-secretase- inhibitory activity
関連化学物質
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Glycine, N-[(3,5-difluorophenyl)acetyl]-L-alanyl-2-phenyl-, (2S)-
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Discovery of canagliflozin, a novel C-glucoside with thiophene ring, as sodium-dependent glucose cotransporter 2 inhibitor for the treatment of type 2 diabetes mellitus (1)
関連化学物質
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2-(5-Bromo-2-methylbenzyl)-5-(4-fluorophenyl)thiophene
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Synthesis and biological evaluation of disulfides as anticancer agents with thioredoxin inhibition
関連化学物質
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ベンゼンチオール
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炭酸水素ナトリウム
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2-((4-chlorophenyl)disulfanyl)pyridine
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Improved, selective, human intestinal carboxylesterase inhibitors designed to modulate 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin (irinotecan; CPT-11) toxicity
関連化学物質
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ピリジン
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N,N'-(1,4-phenylene)bis(2-fluorobenzenesulfonamide)
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Discovery of Novel and Potent Stearoyl Coenzyme A Desaturase 1 (SCD1) Inhibitors as Anticancer Agents
関連化学物質
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3-Pyridazinecarbonyl chloride, 1,6-dihydro-6-oxo- (9CI)
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Discovery and structural development of small molecules that enhance transport activity of bile salt export pump mutant associated with progressive familial intrahepatic cholestasis type 2
関連化学物質
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methyl 3-{N-(1-butyl)-2-chloro-4-{[3-(2,6-dichlorophenyl)-5-isopropylisoxazol-4-yl]methoxy}benzamido}benzoate
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Preparation and biological evaluation of conformationally constrained BACE1 inhibitors
関連化学物質
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ethyl (8R,9S)-8-[[(1R)-1-phenylethyl]amino]-1,4-dioxaspiro[4.5]decane-9-carboxylate
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A concise synthesis of a novel insulin-like growth factor i receptor (IGF-IR) inhibitor
関連化学物質
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トリエチルアミン
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カリウム カーボネート
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フェンチドロン
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Molecular design, synthesis, and hypoglycemic activity of a series of thiazolidine-2,4-diones
関連化学物質
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5-[4-(3-ethyl-3H-imidazo[4,5-b]pyridin-2-ylmethoxy)benzyl]-3-triphenylmethylthiazolidine-2,4-dione
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Development of dimeric modulators for anti-apoptotic Bcl-2 proteins
関連化学物質
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C26H24N2O6S4
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Synthesis and biological evaluation of cinnamido linked pyrrolo[2,1-c][1,4]benzodiazepines as antimitotic agents
関連化学物質
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7-methoxy-8-{6-[2-methoxy-4-[(E)-3-morpholino-3-oxo-1-propenyl]phenoxy]hexyloxy}-(11aS)-1,2,3,11a-tetrahydro-5H-pyrrolo[2,1-c][1,4]benzodiazepin-5-one
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