デザインと統合
一連のピラゾール化合物は，通常異なる化学構造あるいはピラゾール環に結合した官能基を有するように設計·合成されている。これらの化合物は通常COX−2酵素の活性部位と相互作用し，その活性を抑制するように設計されている。
化学原料を購入する必要がある場合は、 要求情報を送信してください最新の見積りを入手してください。
デザインと統合の学術論文
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Synthesis and biological evaluation of the pyrazole class of cyclooxygenase-2-inhibitors
関連化学物質
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3-(4-chlorophenyl)-1-(4-nitrophenyl)-1H-pyrazole-4-carbaldehyde
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Synthesis and phosphodiesterase 5 inhibitory activity of new 5-phenyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one derivatives containing an N-acylamido group on a phenyl ring
関連化学物質
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1-Methyl-5-(5-nitro-2-propoxyphenyl)-3-propyl-1,4-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one
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Synthesis and antibacterial activity of some heterocyclic chalcone analogues alone and in combination with antibiotics
関連化学物質
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3-(3,4-dimethoxyphenyl)-1-(furan-2-yl)prop-2-en-1-one
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Synthesis and evaluation of α-thymidine analogues as novel antimalarials
関連化学物質
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5'-deoxy-5'-(4-nitrobenzamido)thymidine
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SYNTHESIS AND STUDY OF THE ANTIVIRAL ACTIVITY OF PROPANOLAMINE DERIVATIVES
関連化学物質
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Benzamide, N-(2-hydroxy-3-phenoxypropyl)-4-nitro-
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Synthesis and Evaluation of 1- and 2-Substituted Fentanyl Analogues for Opioid Activity
関連化学物質
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Carbamic acid, [2-oxo-2-[(2-phenylethyl)amino]ethyl]-, phenylmethyl ester
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Synthesis and evaluation of [14C]-labelled and fluorescent-tagged paclitaxel derivatives as new biological probes
関連化学物質
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(2aR,4S,4aS,6R,9S,11S,12S,12bS)-6,12b-bis(acetyloxy)-9-({(2R,3S)-3-(benzoylamino)-3-phenyl-2-[(triethylsilyl)oxy]propanoyl}oxy)-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9, 10,11,12,12a,12bdodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxet-12-yl benzoate
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Synthesis and evaluation of novel benzimidazole derivatives as antimicrobial agents
関連化学物質
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N-(4-chloro-3-fluorophenyl)-2-(5-methoxy-1H-benzo[d]imidazol-2-ylthio)acetamide
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Metallocene-based inhibitors of cancer-associated carbonic anhydrase enzymes IX and XII
関連化学物質
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4-(ジメチルアミノ)ピリジン
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AMINES
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4-(5-phenyl-1H-1,2,3-triazol-1-yl)benzenesulfonamide
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Synthesis and evaluation of
aseries of homologues of lobelane at the vesicular monoamine transporter-2関連化学物質
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2-phenyl-6-(3-phenylpropyl)pyridine
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Design and synthesis of 3-[3-(substituted phenyl)-4-piperidin-1-ylmethyl/- 4-morpholin-4-ylmethyl-4,5-dihydro-isoxazol-5-yl]-1H-indoles as potent anti-inflammatory agents
関連化学物質
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5-(1H-indol-3-yl)-3-(4-methylphenyl)-4,5-dihydroisoxazoline
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Design and synthesis of tubulin ligands based on epothilones: A preliminary study
関連化学物質
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1,4-Dioxaspiro[4.5]decane-8-carboxylic acid, 6,6-dimethyl-7-oxo-, phenylmethyl ester
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Indanylidenes. 2. Design and synthesis of (E)-2-(4-chloro-6-fluoro-1-indanylidene)-N-methylacetamide, a potent antiinflammatory and analgesic agent without centrally acting muscle relaxant activity
関連化学物質
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3-(2-chloro-4-methyl-phenyl)-propionic acid
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Design and synthesis of small-molecule fluorescent photoprobes targeted to aminopeptdase N (APN/CD13) for optical imaging of angiogenesis
関連化学物質
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(E)-3-(4-(2-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)ethoxy)-3-methoxyphenyl)acrylic acid
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Design and synthesis of substituted morpholin/piperidin-1-yl-carbamodithioates as promising vaginal microbicides with spermicidal potential
関連化学物質
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sodium piperidin-1-yldithiocarbamate
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1,2,3-Trisubstituted Cyclopropanes as Conformationally Restricted Peptide Isosteres: Application to the Design and Synthesis of Novel Renin Inhibitors
関連化学物質
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(R)-2-BENZYL-SUCCINIC ACID 1-BENZYL ESTER
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Design and synthesis of affinity chromatography ligands for the purification of 5-hydroxyeicosanoid dehydrogenase
関連化学物質
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Hexanoic acid, 5-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-6-oxo-, methyl ester, (5S)-
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Design and synthesis of a new class of cryptophycins based tubulin inhibitors
関連化学物質
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(2S,2'R)-benzyl 2-[(3'-{[(tert-butoxy)carbonyl]amino}propionyl)oxy]-4-methylpentanoate
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Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling
関連化学物質
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N-(4-(4-(2-aminoethylamino)-6-(3-methyl-1H-pyrazol-5-ylamino)pyrimidin-2-ylthio)phenyl)cyclopropanecarboxamide
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Design and synthesis of D-ring steroidal isoxazolines and oxazolines as potential antiproliferative agents against LNCaP, PC-3 and DU-145 cells (Dedicated to Prof. Mushtaq
A. Qureishi for his pioneering contribution to Natural Product Research at University of Kashmir)関連化学物質
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(5'R)-3β-acetoxy-17β-[2-phenyl-4,5-dihydrooxazol-5-yl]androst-5-ene
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Ureidopeptide-based Bronsted bases: Design, synthesis and application to the catalytic enantioselective synthesis of β-amino nitriles from (arylsulfonyl)acetonitriles
関連化学物質
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(9H-fluoren-9-yl)methyl ((R)-1-(3-((S)-(6-methoxyquinolin-4-yl)((1S,2S,4S,5R)-5-vinylquinuclidin-2-yl)methyl)ureido)-2-methylpropyl)carbamate
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Design and Synthesis of Novel Rofecoxib Analogs as Potential Cyclooxygenase (COX-2) Inhibitors: Replacement of the Methylsulfonyl Pharmacophore by a Sulfonylazide Bioisostere
関連化学物質
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4-[4-(4-fluoro-phenyl)-5-oxo-2,5-dihydro-furan-3-yl]-benzenesulfonyl chloride
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Synthesis, molecular modeling and BACE-1 inhibitory study of tetrahydrobenzo[b] pyran derivatives
関連化学物質
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2-amino-4-(4-fluorophenyl)-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile
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Synthesis and antiviral activity of 5-substituted cytidine analogues: Identification of a potent inhibitor of viral RNA-dependent RNA polymerases
関連化学物質
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2-((benzoyloxy)methyl)-5-(4,5-diamino-2-oxopyrimidin-1(2H)yl)tetrahydrofuran-3,4-diyl dibenzoate
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Synthesis and evaluation of curcuminoid analogues as antioxidant and antibacterial agents
関連化学物質
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1,7-bis(4-hydroxy-3-methoxyphenyl)-4-(2-(p-tolyl)hydrazono)hepta-1,6-diene-3,5-dione
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Star-shaped tripodal chemosensors for the detection of aliphatic amines
関連化学物質
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C48H30F9NO3
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Synthesis and biological evaluation of cinnamido linked pyrrolo[2,1-c][1,4]benzodiazepines as antimitotic agents
関連化学物質
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7-methoxy-8-{6-[2-methoxy-4-[(E)-3-morpholino-3-oxo-1-propenyl]phenoxy]hexyloxy}-(11aS)-1,2,3,11a-tetrahydro-5H-pyrrolo[2,1-c][1,4]benzodiazepin-5-one
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Aromatase Inhibitors. Synthesis and Evaluation of Mammary Tumor Inhibiting Activity of 3-Alkylated 3-(4-Aminophenyl)piperidine-2,6-diones
関連化学物質
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2,6-Piperidinedione, 3-(4-aminophenyl)-3-methyl-
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Synthesis and evaluation of novel analogues of vitamin B6 as reactivators of tabun and paraoxon inhibited acetylcholinesterase
関連化学物質
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パラオキソン
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1-phenacyl-3-hydroxy-4-hydroxyiminomethyl-5-hydroxymethyl-2-methyl pyridinium bromide
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tabun
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Synthesis and Biological Evaluation of New Combined α/β-Adrenergic Blockers
関連化学物質
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フマル酸
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1-(3-Methoxymethyl-4-oxiranylmethoxy-phenyl)-ethanone
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Identification of potent non-peptide somatostatin antagonists with sst3 selectivity
関連化学物質
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2-tert-butoxycarbonylamino-3-(1H-indol-3-yl)-propionic acid 2-oxo-1,2-diphenyl-ethyl ester
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Design, synthesis, and evaluation of imidazo[1,2-b]pyridazine derivatives having a benzamide unit as novel VEGFR2 kinase inhibitors
関連化学物質
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N-[4-(imidazo[1,2-b]pyridazin-6-yloxy)phenyl]-N'-phenylurea
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Synthesis and pharmacological evaluation of some novel 4-isopropyl thiazole-based sulfonyl derivatives as potent antimicrobial and antitubercular agents
関連化学物質
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3-(4-bromo-2-fluorobenzylsulfonyl)-5-(4-isopropylthiazol-2-yl)-4-phenyl-4H-1,2,4-triazole
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Synthesis, radiosynthesis and biological evaluation of 1,4-dihydroquinoline derivatives as new carriers for specific brain delivery
関連化学物質
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3-(benzylaminocarbonyl)-6,7-dimethoxy-1-methylquinolinium triflate
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Highly efficient construction of large molecular cavity using 1,3-alternate tetraoxacalix[2]arene[2]triazine as
aplatform関連化学物質
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２，４，６－トリクロロ－１，３，５－トリアジン
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C84H60N16O16
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Design and synthesis of haptens for application to the preparation of chiral 1,4-dihydropyridines
関連化学物質
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5-(Dimethoxy-phosphoryl)-2,6-dimethyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3-carboxylic acid 2-cyano-ethyl ester
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