発見
本稿の用語“発見”とは，mGluR 2のPAMであるこれらのジヒドロピラジン−ベンゾイミダゾール誘導体の同定と開発である。この過程は一般的に広範な研究、化学合成とテストを含み、化合物の有効性、安全性と潜在的な治療応用を評価する。
化学原料を購入する必要がある場合は、 要求情報を送信してください最新の見積りを入手してください。
発見の学術論文
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Discovery of dihydropyrazino-benzimidazole derivatives as metabotropic glutamate receptor-2 (mGluR2) positive allosteric modulators (PAMs)
関連化学物質
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1-Benzimidazoleethanol,2-(hydroxymethyl)-(6CI)
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Discovery of canagliflozin, a novel C-glucoside with thiophene ring, as sodium-dependent glucose cotransporter 2 inhibitor for the treatment of type 2 diabetes mellitus (1)
関連化学物質
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2-(5-Bromo-2-methylbenzyl)-5-(4-fluorophenyl)thiophene
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Tuning the moenomycin pharmacophore to enable discovery of bacterial cell wall synthesis inhibitors
関連化学物質
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phenyl 3,4,6-tri-O-acetyl-2-deoxy-1-thio-2-(2,2,2-trichloroethoxycarbonylamino)-β-D-glucopyranoside S-oxide
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Synthesis and Odor of Aliphatic Musks: Discovery of a New Class of Odorants
関連化学物質
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Ethanone, 1-(5,5-dimethyl-1-cyclohexen-1-yl)-
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Discovery of a novel and potent series of dianilinopyrimidineurea and urea isostere inhibitors of VEGFR2 tyrosine kinase
関連化学物質
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Benzene, 1-[(methylsulfonyl)methyl]-3-nitro-
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Inhibitors of the hepatitis C virus NS3 protease with basic amine functionality at the P3-amino acid N-terminus: Discovery and optimization of a new series of P2-P4 macrocycles
関連化学物質
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(2R,4S,7S,14E)-7-cyclohexyl-23-methoxy-4-(methoxycarbonyl)-6-oxo-20-phenyl-3,4,6,7,8,9,10,11,12,13-decahydro-2H-16,18-etheno-2,5-methanopyrido[3,4-r][1,5,8]oxadiazacyclononadecin-8-ium trifluoroacetate
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Discovery of orally active carboxylic acid derivatives of 2-phenyl-5-trifluoromethyloxazole-4-carboxamide as potent diacylglycerol acyltransferase-1 inhibitors for the potential treatment of obesity and diabetes
関連化学物質
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4-(4-{4-[(2-phenyl-5-trifluoromethyloxazole-4-carbonyl)amino]phenyl}piperazine-1-carbonyl)-trans-cyclohexanecarboxylic acid
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Discovery of EBI-907: A highly potent and orally active B-RafV600Einhibitor for the treatment of melanoma and associated cancers
関連化学物質
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1-Bromo-4-(bromomethyl)-2-methoxybenzene
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Discovery, characterization, and effects on renal fluid and electrolyte excretion of the Kir4.1 potassium channel pore blocker, VU0134992
関連化学物質
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2-(2-bromo-4-isopropylphenoxy)-N-(2,2,6,6-tetramethylpiperidin-4-yl)acetamide
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Discovery of a series of 5-phenyl-2-furan derivatives containing 1,3-thiazole moiety as potent Escherichia coli β-glucuronidase inhibitors
関連化学物質
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5-(4-FLUOROPHENYL)FURAN-2-CARBONYL CHLORIDE
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Design and discovery of 2-oxochromene derivatives as liver X receptor β-selective agonists
関連化学物質
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5-(4-methoxyphenyl)-5-methyl-3-(4-(2-oxo-8-n-propyl-4-(trifluoromethyl)-2H-chromen-7-yloxy)butyl)imidazolidine-2,4-dione
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Discovery of pyrrolidine-2,3-diones as novel inhibitors of p. Aeruginosa pbp3
関連化学物質
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[1-(4-Chloro-phenyl)-meth-(E)-ylidene]-[2-(1H-indol-3-yl)-ethyl]-amine
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Discovery of dihydroisoquinolinone derivatives as novel inhibitors of the p53-MDM2 interaction with a distinct binding mode
関連化学物質
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[4-((R)-sec-Butoxy)-3-methoxy-phenyl]-acetic acid
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Discovery of a potent small molecule IL-2 inhibitor through fragment assembly
関連化学物質
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3-chloromethyl-benzoic acid allyl ester
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Discovery of benzophosphadiazine drug candidate IDX375: A novel hepatitis C allosteric NS5B RdRp inhibitor
関連化学物質
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(2,5-diaminophenyl)-phosphonic acid diethyl ester
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Discovery, design, and optimization of isoxazole azepine BET inhibitors
関連化学物質
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methyl 2-bromo-4,5-dimethylthiophene-3-carboxylate
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Conjugation of a nonspecific antiviral sapogenin with a specific HIV fusion Inhibitor: A promising strategy for discovering new antiviral therapeutics
関連化学物質
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tert-butyldiphenylsilyl 3β-hydroxylup-20(29)-en-28-oate
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Discovery of multifunctional anti-Alzheimer's agents with a unique mechanism of action including inhibition of the enzyme butyrylcholinesterase and γ-aminobutyric acid transporters
関連化学物質
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(2R,3S)-3-amino-1-((3-(tert-butyl)benzyl)amino)-4-phenylbutan-2-ol
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2,7-Disubstituted-pyrrolo[2,1- f ][1,2,4]triazines: New variant of an old template and application to the discovery of anaplastic lymphoma kinase (ALK) inhibitors with in vivo antitumor activity
関連化学物質
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[4-(morpholin-4-yl)-phenyl]-(7-phenyl-pyrrolo[2,1-f][1,2,4]triazin-2-yl)-amine
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Discovery and structure-activity relationship of (1R)-8-chloro-2,3,4,5- tetrahydro-1-methyl-1H-3-benzazepine (Lorcaserin), a selective serotonin 5-HT2C receptor agonist for the treatment of obesity
関連化学物質
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N-[2-(4-chlorophenyl)ethyl]-1-amino-2-methylpropanol
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The discovery and optimization of benzimidazoles as selective NaV1.8 blockers for the treatment of pain
関連化学物質
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N-(4-(2-cyanopropan-2-yl)-2-nitrophenyl)acetamide
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Discovery of a novel nonphosphorylated pentapeptide motif displaying high affinity for Grb2-SH2 domain by the utilization of 3′-substituted tyrosine derivatives
関連化学物質
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3-Acetyl-N-[(phenylMethoxy)carbonyl]-O-(phenylMethyl)-L-tyrosine Methyl Ester
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(Phosphinyloxy)acyl amino acid inhibitors of angiotensin converting enzyme (ACE). 1. Discovery of (S)-1-[6-amino-2-[[hydroxy(4-phenylbutyl)phosphinyl]oxy]-1-oxohexyl]- -proline, a novel orally active inhibitor of ACE
関連化学物質
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L-Proline, 1-[2-hydroxy-1-oxo-6-[[(phenylmethoxy)carbonyl]amino]hexyl]-, phenylmethyl ester, (S)-
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Development of a New Structural Class of Broadly Acting HCV Non-Nucleoside Inhibitors Leading to the Discovery of MK-8876
関連化学物質
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methyl 2-(5-bromo-2-(tert-butyldimethylsilyloxy)phenyl)-3-(4-fluorophenyl)-3-oxopropanoate
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Discovery of novel 2-anilinopyrazolo[1,5-a]pyrimidine derivatives as c-Src kinase inhibitors for the treatment of acute ischemic stroke
関連化学物質
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Propanedinitrile, [[(2-methoxyphenyl)amino](methylthio)methylene]-
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Discovery of 8-Amino-imidazo[1,5-a]pyrazines as Reversible BTK Inhibitors for the Treatment of Rheumatoid Arthritis
関連化学物質
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4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-N-(4-trifluoromethyl-pyridin-2-yl)benzamide
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Discovery of novel heat shock protein (Hsp90) inhibitors based on luminespib with potent antitumor activity
関連化学物質
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ethyl 5-(2,4-dihydroxy-5-isopropylphenyl)-3-(ethylcarbamoyl)-4,5'-biisoxazole-3'-carboxylate
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Discovery of 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4, 5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide (Apixaban, BMS-562247), a highly potent, selective, efficacious, and orally bioavailable inhibitor of blood coagulation factor Xa
関連化学物質
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1-(4-Methoxyphenyl)-6-(4-iodophenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid ethyl ester
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Discovery of RWJ-54428 (MC-02,479), a new cephalosporin active against resistant gram-positive bacteria
関連化学物質
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ethyl (2-aminothiazol-4-yl)-2-(Z)-(trityloxyimino)acetate
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Discovery of
anew potent bisamide FMS kinase inhibitor関連化学物質
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N-(1-(3-aminophenyl)-1H-pyrrolo[3,2-c]pyridin-4-yl)benzamide
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Discovery and synthesis of c-nucleosides as potential new anti-HCV agents
関連化学物質
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C28H26Cl6O5
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Discovery and Characterization of 2-Aminooxazolines as Highly Potent, Selective, and Orally Active TAAR1 Agonists
関連化学物質
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5-(2-chlorophenyl)-5-methylimidazolidine-2,4-dione
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Discovery of novel Tricyclic full agonists for the G-protein-coupled niacin receptor 109A with minimized flushing in rats
関連化学物質
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3-(1,2,3,4-Tetrahydro-6-methoxy-1-oxo-2-naphthoyl)propionicacid
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Discovery and evaluation of N-(triazin-1,3,5-yl) phenylalanine derivatives as VLA-4 integrin antagonists.
関連化学物質
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S-ethyl 3-[4-(3,5-dichloropyrid-4-ylcarboxamido)-phenyl]-2-(4-methoxy-6-dimethylamino-1,3,5-triazin-2-ylamino)propionate
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Discovery and synthesis of N2,N4-substitued- cycloalkyl[d]pyrimidine-2,4-diamine analogs: The first examples of small-molecular FGFR-1 activator
関連化学物質
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5-[[4-[N-(2,3-dimethyl-2H-indazol-6-yl)-N-methylamino]-6,7-dihydro-5H-cyclopenta[d]pyrimidin-2-yl]amino]-2-methyl-benzenesulfonamide
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Discovery of novel N -β- d -Xylosylindole derivatives as sodium-dependent glucose cotransporter 2 (SGLT2) inhibitors for the management of hyperglycemia in diabetes
関連化学物質
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3-benzyl-1-(β-D-xylopyranosyl)-1H-indole
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Discovery of orally available integrin α5β1 antagonists
関連化学物質
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C28H31NO5
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Discovery of (Z)-2-phenyl-3-(1H-pyrrol-2-yl)acrylonitrile derivatives active against Haemonchus contortus and Ctenocephalides felis (cat flea)
関連化学物質
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Benzeneacetonitrile, 4-chloro-a-(1H-pyrrol-2-ylmethylene)-, (Z)-
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Discovery of TAK-659 an orally available investigational inhibitor of Spleen Tyrosine Kinase (SYK)
関連化学物質
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methyl 2-chloro-4-methyl-6-(m-tolylamino)pyrimidine-5-carboxylate
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Discovery of potent, selective, orally active, nonpeptide inhibitors of human mast cell chymase
関連化学物質
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Benzene, 1-fluoro-4-[(1E)-2-isocyanatoethenyl]- (9CI)
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Discovery of an Isothiazole-Based Phenylpropanoic Acid GPR120 Agonist as a Development Candidate for Type 2 Diabetes
関連化学物質
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ethyl 3-(4-chlorophenyl)-5-methylisothiazole-4-carboxylate
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Discovery of New Selenoureido Analogues of 4-(4-Fluorophenylureido)benzenesulfonamide as Carbonic Anhydrase Inhibitors
関連化学物質
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o-chlorophenyl isoselenocyanate
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